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Dth

رقم الكتالوجGC91440 Copy One-Click Copy Product Info

Dth هو مخلب يستهدف تحليل البروتينات (PROTAC) ويتألف من المسحة الضوئية لـ RNA DFHBI والمركب المناعي التحكمي ثاليدومايد.

Products are for research use only. Not for human use. We do not sell to patients.

Dth التركيب الكيميائي

الحجم السعر المخزون الكميّة
500μg
139٫00
متوفر
1mg
249٫00
متوفر
5mg
1109٫00
متوفر

Tel:(909) 407-4943 Email: sales@glpbio.com


مراجعات العميل

بناء على آراء العملاء.

Sample solution is provided at 25 µL, 10mM.



Description of Dth

Dth is a proteolysis-targeting chimera (PROTAC) composed of the fluorescent probe for RNA DFHBI and the immunomodulatory compound thalidomide .1 It binds to a genetically expressed RNA aptamer comprising Broccoli and a modifiable and selective protein targeting sequence and induces degradation of mCherry in HEK293T cells when used at a concentration of 20 µM. Dth (20 µM) induces degradation of the NF-κB subunit p50, as well as p50 and the E2F transcription factor subtype E2F1, in MCF-7 cells.

Chemical Properties of Dth

Cas No. SDF
Formula C30H29F2N5O6 M.Wt 593.6
الذوبان Ethanol: 1 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of Dth

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 1.6846 mL 8.4232 mL 16.8464 mL
5 mM 336.9 μL 1.6846 mL 3.3693 mL
10 mM 168.5 μL 842.3 μL 1.6846 mL
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** عند إعداد حلول المخزون، دائمًا استخدم الوزن الجزيئي الخاص بالدفعة للمنتج على ملصق القارورة MSDS / CoA (متوفر عبر الإنترنت).

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In vivo Formulation Calculator (Clear solution) of Dth

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % saline
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

Quality Control & SDS

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Review for Dth

Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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