Quilseconazole (Synonyms: VT-1129) |
| رقم الكتالوجGC37061 |
كويلسيكونازول (VT-1129) هو مثبط فعّال للفطريات Cyp51 (لانوستيرول 14-α-demethylase) ، يرتبط بإحكام بالمكورات الخفية CYP51 ، ولكنه يثبط بشكل ضعيف إنزيمات CYP450 البشرية
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Cas No.: 1340593-70-5
Sample solution is provided at 25 µL, 10mM.
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Quilseconazole (VT-1129) is a potent, orally active fungal Cyp51 (lanosterol 14-α-demethylase) inhibitor, binds tightly to cryptococcal CYP51, but weakly inhibits humans CYP450 enzymes[1]. Fungal, Cyp51[1]
[1]. Lockhart SR, et al. The Investigational Fungal Cyp51 Inhibitor VT-1129 Demonstrates Potent In Vitro Activity against Cryptococcus neoformans and Cryptococcus gattii. Antimicrob Agents Chemother. 2016 Mar 25;60(4):2528-31.
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