YUKA1 |
| رقم الكتالوجGC37956 |
YUKA1 هو مثبط Lysine demethylase 5A (KDM5A) قوي ونفاذ للخلايا ، مع IC50 من 2.66 ميكرومتر ، وأقل نشاطًا على KDM5C (IC50 ، 7.12 ميكرومتر) ، وغير نشط على KDM5B أو KDM6A أو KDM6BYUKA1 يزيد من مستويات H3K4me3 في الخلايا البشرية مع نشاط مضاد للسرطان
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 708991-09-7
Sample solution is provided at 25 µL, 10mM.
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YUKA1 is a potent and cell permeable Lysine demethylase 5A (KDM5A) inhibitor, with an IC50 of 2.66 μM, less active on KDM5C (IC50, 7.12 μM), and is inactive on KDM5B, KDM6A or KDM6B. YUKA1 increases H3K4me3 levels in human cells with anti-cancer activity[1]. IC50: 2.66 μM (KDM5A), 7.12 μM (KDM5C)[1]
[1]. Gale M, et al. Screen-identified selective inhibitor of lysine demethylase 5A blocks cancer cell growth and drug resistance. Oncotarget. 2016 Jun 28;7(26):39931-39944.
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