Pyrenophorol is a fungal metabolite that has been found in Alternaria and has diverse biological activities.1,2,3 It inhibits human topoisomerase II α when used at concentrations of 75 and 100 μM.1 It is active against S. cerevisiae (MIC = 4 μM) and M. violaceum.2 Pyrenophorol induces leaf necrosis and chlorophyll retention in wild oats when used at a concentration of 64 μM.3
References
1. Jarolim, K., Del Favero, G., Ellmer, D., et al. Dual effectiveness of Alternaria but not Fusarium mycotoxins against human topoisomerase II and bacterial gyrase. Arch. Toxicol. 91(4), 2007-2016 (2016).
2. Sumarah, M.W., Kesting, J.R., S•rensen, D., et al. Antifungal metabolites from fungal endophytes of Pinus strobus. Phytochemistry 72(14-15), 1833-1837 (2011).