MC-GGFG-DX8951 (Synonyms: MC-GGFG-DX8951) |
| رقم الكتالوجGC39309 |
MC-GGFG-DX8951 (MC-GGFG-DX8951) عبارة عن اتحاد رابط مخدرات لـ ADC. MC-GGFG-DX8951 هو مشتق DX8951 (مثبط DNA topoisomerase I) مع رابط MC-GGFG قابل للانقسام بالبروتياز. يُظهر MC-GGFG-DX8951 نشاطًا مضادًا للورم ويمكن استخدامه لإعداد متقارن أضداد DX8951 (ADC).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1600418-29-8
Sample solution is provided at 25 µL, 10mM.
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MC-GGFG-DX8951 is a drug-linker conjugate for ADC with antitumor activity by using DX8951 (a DNA topoisomerase I inhibitor), linked via the protease cleavable MC-GGFG linker[1].
[1]. Nakada T, et al. Novel antibody drug conjugates containing exatecan derivative-based cytotoxic payloads. Bioorg Med Chem Lett. 2016 Mar 15;26(6):1542-1545.
Average Rating: 5 (Based on Reviews and 31 reference(s) in Google Scholar.)
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