dMCL1-2 |
| رقم الكتالوجGC35882 |
dMCL1-2 هو PROTAC قوي وانتقائي لسرطان الدم في الخلايا النخاعية 1 (MCL1) (أحد أفراد عائلة Bcl-2) استنادًا إلى Cereblon ، والذي يرتبط بـ MCL1 بقيمة 30 نانومترينشط dMCL1-2 آلية موت الخلايا المبرمج الخلوي عن طريق تحلل MCL1
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Cas No.: 2351218-88-5
Sample solution is provided at 25 µL, 10mM.
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dMCL1-2 is a potent and selective degrader of myeloid cell leukemia 1 (MCL1) based on PROTAC, which binds to MCL1 with a KD of 30 nM. dMCL1-2 activats the cellular apoptosis machinery by degradation of MCL1[1]. KD: 30 nM (MCL1)[1]
[1]. Papatzimas JW, et al. From Inhibition to Degradation: Targeting the Antiapoptotic Protein Myeloid Cell Leukemia 1 (MCL1). J Med Chem. 2019 Jun 13;62(11):5522-5540.
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