Moenomycin Complex

Moenomycin Complex is a mixture of moenomycin A, A₁₂, C₁, C₃ and C₄ isolated from several Streptomyces species that directly inhibit bacterial peptidoglycan glycosyltransferases (PGTs)^{[1, 2]}. Moenomycin A is a member of the phospholipid antibiotic family, which is the only known natural product that directly targets extracellular PGTs involved in bacterial cell wall biosynthesis^[3]. The minimum inhibitory concentration of moenomycin A against various Gram-positive bacteria ranges from 1 to 100ng/mL^[4]. Moenomycin can be used as a feed additive and growth promoter^[5].

References:
[1] Zehl M, Pittenauer E, Rizzi A, et al. Characterization of moenomycin antibiotic complex by multistage MALDI-IT/RTOF-MS and ESI-IT-MS[J]. Journal of the American Society for Mass Spectrometry, 2006, 17: 1081-1090.
[2] Yuan Y. Targeting the bacterial cell wall-structural insight into peptidoglycan glycosyltransferases and moenomycin inhibition[M]. Harvard University, 2008.
[3] Ostash B, Saghatelian A, Walker S. A streamlined metabolic pathway for the biosynthesis of moenomycin A[J]. Chemistry & biology, 2007, 14(3): 257-267.
[4] Ostash B, Walker S. Moenomycin family antibiotics: chemical synthesis, biosynthesis, and biological activity[J]. Natural product reports, 2010, 27(11): 1594-1617.
[5] Tang Y, Yang G, Ma Y, et al. Development, validation, and implementation of an ultratrace analysis method for the determination of moenomycin A, in aquatic animal products[J]. Analytical and Bioanalytical Chemistry, 2024, 416(3): 745-757.