ADDA 5 hydrochloride |
| رقم الكتالوجGC32251 |
ADDA 5 هيدروكلوريد هو مثبط جزئي غير تنافسي للسيتوكروم سي أوكسيديز (CcO) ، مع IC50s من 18.93 ميكرومتر و 31.82 ميكرومتر من أجل CcO المنقى من الورم الدبقي البشري وقلب الأبقار ، على التوالي
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 473268-46-1
Sample solution is provided at 25 µL, 10mM.
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ADDA 5 hydrochloride is a partial non-competitive inhibitor of cytochrome c oxidase (CcO), with IC50s of 18.93 μM and 31.82 μM for purified CcO from human glioma and bovine heart, respectively.
ADDA 5 hydrochloride is a partial non-competitive inhibitor of CcO, with IC50s of 18.93 μM and 31.82 μM for purified CcO from human glioma and bovine heart, respectively. ADDA 5 inhibits CcO activity in UTMZ and Jx22-derived GSCs, with IC50s of 21.4 ± 3.9 μM and 15.5 ± 2.8 μM. ADDA 5 (25 μM) shows a growth inhibitory effect on UTMZ cells, with an EC50 of 8.17 μM[1].
ADDA 5 (8 mg/kg, i.p.) significantly suppresses the growth of tumor in mice. ADDA 5 does not causes detectable toxicity at up to 80 mg/kg in mice[1].
[1]. Oliva CR, et al. Identification of Small Molecule Inhibitors of Human Cytochrome c Oxidase That Target Chemoresistant Glioma Cells. J Biol Chem. 2016 Nov 11;291(46):24188-24199. Epub 2016 Sep 27.
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