IF 16
PMID: 41459756 ↗Parathyroid hormone (1-34) (human)
Catalog No.: GP10069Purity:>99.50%Synonyms: Teriparatide Acetate; Human parathyroid hormone-(1-34); hPTH (1-34)
Parathyroid hormone (1-34) (human) is the N-terminal fragment (34 amino acids) of human Parathyroid hormone (PTH) and is an agonist of the Parathyroid hormone 1 (PTH1) receptor.
المنتجات مخصصة للاستخدام البحثي فقط، وليست للاستخدام البشري. نحن لا نبيع للمرضى.
Cas No.: 52232-67-4
10mM (in 1mL Water)In Stock
$253.00
1
1mgIn Stock
$56.00
1
5mgIn Stock
$69.00
1
10mgIn Stock
$94.00
1
50mgIn Stock
$280.00
1
100mgIn Stock
$364.00
1
| Pack Size | Price | Availability | Quantity | Action |
|---|---|---|---|---|
| 10mM (in 1mL Water) | $253.00 | In Stock | 1 | |
| 1mg | $56.00 | In Stock | 1 | |
| 5mg | $69.00 | In Stock | 1 | |
| 10mg | $94.00 | In Stock | 1 | |
| 50mg | $280.00 | In Stock | 1 | |
| 100mg | $364.00 | In Stock | 1 |
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المراجع (Citations)
2 publicationsمنشورات الباحثين الذين استخدموا هذا المنتجالوصف (Description)
Parathyroid hormone (1-34) (human) is the N-terminal fragment (34 amino acids) of human Parathyroid hormone (PTH) and is an agonist of the Parathyroid hormone 1 (PTH1) receptor[1]. PTH is essential for the regulation of extracellular Ca2+ and phosphate metabolism[2]. Parathyroid hormone (1-34) (human) can be used to treat osteoporosis. Injection of Parathyroid hormone (1-34) (human) can increase bone formation and bone mass without causing hypercalcemia[3, 4].
In vitro, Parathyroid hormone (1-34) (human) (0, 1, 10, 100nM) treatment of primary human osteoblasts for 24h induced an increase in angiopoietin 1 (Ang-1) mRNA expression. The 10nM dose increased the expression of Ang-1 mRNA by 2-fold (207%±6.4), but increasing the dose to 100nM did not further increase the expression level of Ang-1 mRNA[5].
In vivo, subcutaneous administration of Parathyroid hormone (1-34) (human) (20μg/kg/day) to mature rabbits for 4 weeks increased the cortical bone porosity, number and density, as well as the cortical area, thickness and bone mineral content (BMC) of the distal femoral shaft, but had no significant effect on volumetric bone mineral density (BMD)[6].
References:
[1] Hoare S R J, Usdin T B. Molecular mechanisms of ligand recognition by parathyroid hormone 1 (PTH1) and PTH2 receptors[J]. Current pharmaceutical design, 2001, 7(8): 689-713.
[2] Goltzman D. Physiology of parathyroid hormone[J]. Endocrinology and Metabolism Clinics, 2018, 47(4): 743-758.
[3] Kim E S, Keating G M. Recombinant human parathyroid hormone (1–84): a review in hypoparathyroidism[J]. Drugs, 2015, 75: 1293-1303.
[4] Neer R M, Arnaud C D, Zanchetta J R, et al. Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis[J]. New England journal of medicine, 2001, 344(19): 1434-1441.
[5] Park J H, Song H I, Rho J M, et al. Parathyroid hormone (1-34) augments angiopoietin-1 expression in human osteoblast-like cells[J]. Experimental and clinical endocrinology & diabetes, 2006, 114(08): 438-443.
[6] Iwamoto J, Seki A, Nango N. Influence of teriparatide and ibandronate on cortical bone in New Zealand white rabbits: A HR-QCT study[J]. Calcified tissue international, 2016, 99(5): 535-542.
البروتوكول (Protocol)
| Cell experiment [1]: | |
|
Cell lines |
Primary cultured human osteoblasts |
|
Preparation Method |
Primary cultured human osteoblasts were cultured in the presence of 0, 1, 10, and 100nM Parathyroid hormone (1-34) (human) for 24h. The expression of Ang-1 mRNA was analyzed by RT-PCR. |
|
Reaction Conditions |
0, 1, 10, 100nM; 24h |
|
Applications |
Parathyroid hormone (1-34) (human) induced an increase in Ang-1 mRNA expression. The Ang-1 mRNA levels, at 10nM Parathyroid hormone (1-34) (human), were 2-fold (207%±6.4) the levels of the control. Further increases in the concentration of Parathyroid hormone (1-34) (human) (to 100nM) did not further increase the levels of Ang-1 mRNA expression. |
| Animal experiment [2]: | |
|
Animal models |
Female New Zealand white rabbits |
|
Preparation Method |
Rabbits were randomized into six groups of 7 animals each as follows: 4-week vehicle administration group, 4-week Parathyroid hormone (1-34) (human) (TPTD) administration group (20μg/kg/day, s.c.), 12-week vehicle administration group, 4-week TPTD administration+8-week vehicle administration group, 4-week TPTD administration+8-week lower-dose ibandronate (IBN) administration group (20μg/kg, s.c., every 4 weeks), and 4-week TPTD administration+8-week higher-dose IBN administration group (100μg/kg, s.c., every 4 weeks). After the 4- or 12-week experimental period, the cortical bone of the distal femoral diaphysis was processed for HR-QCT analysis. |
|
Dosage form |
20μg/kg/day, for 4 weeks; s.c. |
|
Applications |
Parathyroid hormone (1-34) (human) administration increased the pore ratio, number, and density as well as the cortical area, thickness, and bone mineral content (BMC), without significant influencing the volumetric bone mineral density (BMD). |
|
References: |
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وثائق المنتج (Product Documents)
Purity:>99.50%Appearance:A solid
الخصائص الكيميائية (Chemical Properties)
رقم CAS
52232-67-4
المرادفات
Teriparatide Acetate; Human parathyroid hormone-(1-34); hPTH (1-34)
الصيغة الجزيئية
C181H291N55O51S2
الوزن الجزيئي
4117.75
الذوبانية
100 mg/mL in Water；100 mg/mL in DMSO
التخزين
-20°C, away from moisture and light
إرشادات عامة
اختر مذيبًا مناسبًا وفقًا لبيانات ذوبانية المنتج. بعد التحضير، قسّم المحلول المخزون إلى أجزاء لتجنب دورات التجميد والذوبان المتكررة.
استخدم المحاليل المخزونة خلال 6 أشهر عند حفظها في -80°C، أو خلال شهر واحد عند حفظها في -20°C.
لتحسين الذوبانية، سخّن الأنبوب إلى 37°C وعرّضه للموجات فوق الصوتية لمدة مناسبة.
استخدم المحاليل المخزونة خلال 6 أشهر عند حفظها في -80°C، أو خلال شهر واحد عند حفظها في -20°C.
لتحسين الذوبانية، سخّن الأنبوب إلى 37°C وعرّضه للموجات فوق الصوتية لمدة مناسبة.
شروط الشحن
تُشحن عينات التقييم مع عبوات تبريد. وتُشحن الأحجام الأخرى المتاحة في درجة حرارة الغرفة، أو مع عبوات تبريد عند الطلب.
الحاسبات (Calculators)المولارية / التخفيف / الوزن الجزيئي / تحويل الوحدات / تركيبة داخل الجسم الحي / الذوبانية
g/mol
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