Peimisine is a kind of bioactive alkaloids found in Fritillaria bulbs which can inhibit angiotensin converting enzyme (ACE) activity with an IC50 of 526.5μM [1]. Peimisine has anti-acute lung injury effect and has obvious cytotoxicity against various tumor cells [2, 3].
Peimisine (10, 20 and 40μM; 24h) reduced the reactive oxygen species (ROS), malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE) content and restored the level of superoxide dismutase (SOD) in cigarette smoke extract (CSE)-induced BEAS-2B cells; Peimisine (10, 20 and 40μM; 24h) significantly decreased the number of apoptotic cells and the cell apoptosis rate in CSE-induced BEAS-2B cells [4]. Peimisine (160μM; 24h) significantly upregulated the expression of ADRB2 and NOS3 and downregulated the expression of SRC and MMP2 in BEAS-2B cells stimulated with CSE [5].
Peimisine (5 and 15mg/kg; 7d; p.o.) significantly alleviated the disease signs of colitis C57BL/C mice; Peimisine (5 and 15mg/kg; 7d; p.o.) significantly downregulated the expression levels of CD68 and CD11b in colitis C57BL/C mice [6].
References:
[1] Oh H, Kang D G, Lee S, et al. Angiotensin converting enzyme (ACE) inhibitory alkaloids from Fritillaria ussuriensis [J]. Planta medica, 2003, 69(6): 564-565.
[2] Jin X, Gao X, Lan M, et al. Study the mechanism of peimisine derivatives on NF-κB inflammation pathway on mice with acute lung injury induced by lipopolysaccharide [J]. Chemical biology & drug design, 2022, 99(5): 717-726.
[3] Wang D, Jiang Y, Wu K, et al. Evaluation of antitumor property of extracts and steroidal alkaloids from the cultivated Bulbus Fritillariae ussuriensis and preliminary investigation of its mechanism of action [J]. BMC complementary and alternative medicine, 2015, 15: 29.
[4] Liu C, Zhu X, Aga E, et al. Ebeiedinone and peimisine inhibit cigarette smoke extract-induced oxidative stress injury and apoptosis in BEAS-2B cells [J]. Cell stress & chaperones, 2024, 29(6): 697-708.
[5] Xian M, Xu J, Zheng Y, et al. Network pharmacology and experimental verification reveal the regulatory mechanism of Chuanbeimu in treating chronic obstructive pulmonary disease [J]. International journal of chronic obstructive pulmonary disease, 2024, 19: 799-813.
[6] Li Y, Yang X, Han J, et al. Peimisine ameliorates DSS-induced colitis by suppressing Jak-Stat activation and alleviating gut microbiota dysbiosis in mice [J]. The Journal of pharmacy and pharmacology, 2024, 76(5): 545-558.