Pluviatolide is a lignan that has been found in B. chinense and has diverse biological activities, including antioxidant, enzyme inhibitory, and antispasmodic properties.1,2,3 It scavenges ABTS and 2,2-diphenyl-1-picrylhydrazyl radicals in cell-free assays (IC50s = 23.2 and 88.5 μM, respectively).1 Pluviatolide inhibits matrix metalloproteinase-7 (MMP-7) with an IC50 value of 260 μM.2 It decreases contractions induced by acetylcholine in isolated guinea pig ileum when used at concentrations of 30 and 100 μM.3
|1. Li, D.-Q., Wang, D., Zhou, L., et al. Antioxidant and cytotoxic lignans from the roots of Bupleurum chinense. J. Asian Nat. Prod. Res. 19(5), 519-527 (2017).|2. Muta, Y., Oyama, S., Umezawa, T., et al. Inhibitory effects of lignans on the activity of human matrix metalloproteinase 7 (matrilysin). J. Agric. Food Chem. 52(19), 5888-5894 (2004).|3. Zhang, G., Shimokawa, S., Mochizuki, M., et al. Chemical constituents of Aristolochia constricta: Antispasmodic effects of its constituents in guinea-pig ileum and isolation of a diterpeno-lignan hybrid. J. Nat. Prod. 71(7), 1167-1172 (2008).