GLPBio

Procyanidin B2

Catalog No.: GN10599Purity:>98.00%Synonyms: (-)-Epicatechin-(4β→8)-(-)-epicatechin, Proanthocyanidin B2, Procyanidol B2
COASDSData Sheet
Procyanidin B2 (PB2), an antioxidant from the proanthocyanidin flavonoid polyphenol group, is found in plants like grape seeds, berries, cocoa, and tea, offering pharmacological benefits including anti-oxidative and anti-inflammatory effects.

المنتجات مخصصة للاستخدام البحثي فقط، وليست للاستخدام البشري. نحن لا نبيع للمرضى.

Procyanidin B2
Cas No.: 29106-49-8
10mM (in 1mL DMSO)In Stock
$104.00
1
1mgIn Stock
$30.00
1
5mgIn Stock
$95.00
1
10mgIn Stock
$161.00
1
25mgIn Stock
$315.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

المراجع (Citations)

لا تتوفر حاليًا مراجع لهذا المنتج. فيما يلي مجموعة مختارة من المنشورات التي تستشهد بمنتجات GlpBio.
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    632, 686–694 (2024)
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    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    388(6745) (2025)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

الوصف (Description)

Procyanidin B2 (PB2), an antioxidant from the proanthocyanidin flavonoid polyphenol group, is found in plants like grape seeds, berries, cocoa, and tea, offering pharmacological benefits including anti-oxidative and anti-inflammatory effects [1-3].

Procyanidin B2, when administered at concentrations ranging from 0 to 10 μM for 24 h, suppresses the secretion of sFlt-1 from primary placental tissues andendothelial cells [4]. Additionally, at concentrations of 1 to 2.5 μM, Procyanidin B2 enhances the angiogenic function, survival, and migration of Endothelial Progenitor Cells (EPCs) exposed to high glucose (HG) conditions [5].

Procyanidin B2 (PB2), administered intravenously at doses of 0.5, 1, or 2 mg/kg, contributes to the treatment of sepsis-induced Acute Lung Injury (ALI) by regulating cytokine storms and mitigating inflammation through modulation of the TLR4/NF-κB, PI3K/Akt, Hippo, and Rho signaling pathways [6]. Furthermore, Procyanidin B2 (50 mg/kg/day) administered orally for 6 weeks attenuates liver injury and hepatocyte pyroptosis in mice exposed to nicotine [7].

References:

[1]. Chen J, Zhong K, et,al. Procyanidin B2: A promising multi-functional food-derived pigment for human diseases. Food Chem. 2023 Sep 15;420:136101. doi: 10.1016/j.foodchem.2023.136101. Epub 2023 Apr 7. Erratum in: Food Chem. 2024 Feb 1;433:137359. PMID: 37059021.

[2]. Zhang JQ, Gao BW, et,al. Critical Role of FoxO1 in Granulosa Cell Apoptosis Caused by Oxidative Stress and Protective Effects of Grape Seed Procyanidin B2. Oxid Med Cell Longev. 2016;2016:6147345. doi: 10.1155/2016/6147345. Epub 2016 Jan 19. PMID: 27057282; PMCID: PMC4745910.

[3]. Kopustinskiene DM, Savickas A, et,al. Direct effects of (-)-epicatechin and procyanidin B2 on the respiration of rat heart mitochondria. Biomed Res Int. 2015;2015:232836. doi: 10.1155/2015/232836. Epub 2015 Feb 24. PMID: 25811024; PMCID: PMC4354975.

[4]. Liu L, Wang R, et,al. Procyanidin B2 ameliorates endothelial dysfunction and impaired angiogenesis via the Nrf2/PPARγ/sFlt-1 axis in preeclampsia. Pharmacol Res. 2022 Mar;177:106127. doi: 10.1016/j.phrs.2022.106127. Epub 2022 Feb 10. PMID: 35150862.

[5]. Fan J, Liu H, et,al. Procyanidin B2 improves endothelial progenitor cell function and promotes wound healing in diabetic mice via activating Nrf2. J Cell Mol Med. 2021 Jan;25(2):652-665. doi: 10.1111/jcmm.16111. Epub 2020 Nov 20. PMID: 33215883; PMCID: PMC7812287.

[6]. Kim GO, Park DH, et,al. Procyanidin B2 Attenuates Sepsis-Induced Acute Lung Injury via Regulating Hippo/Rho/PI3K/NF-κB Signaling Pathway. Int J Mol Sci. 2023 Apr 27;24(9):7930. doi: 10.3390/ijms24097930. PMID: 37175637; PMCID: PMC10177954.

[7]. Liu J, Yao Q, et,al. Procyanidin B2 Attenuates Nicotine-Induced Hepatocyte Pyroptosis through a PPARγ-Dependent Mechanism. Nutrients. 2022 Apr22;14(9):1756. doi: 10.3390/nu14091756. PMID: 35565726; PMCID: PMC9103831.

البروتوكول (Protocol)

Cell experiment [1]:

Cell lines

HUVECs( Human Umbilical Vein Endothelial Cells，HUVEC)

Preparation method

HUVECs were treated with different concentrations of procyanidin B2 (0, 2.5, 5, and 10 μM) for 24 h.

Reaction Conditions

0-10 μM; 24 h

Applications

Procyanidin B2 inhibits sFlt-1 secretion from HUVEC in a concentration-dependent manner.

Animal experiment [2]:

Animal models

Male C57BL/6 mice (27 g; 6–7 weeks old)

Preparation method

LPS was injected into the mice via intraperitoneal injection at a dose of 5 mg/kg with 0.2% DMSO. One hour and 12 h after the LPS injection, the mice were given intravenous doses of Procyanidin B2 (0.5, 1, or 2 mg/kg).

Dosage form

0.5, 1, or 2 mg/kg; i.v

Applications

Procyanidin B2 Alleviated Acute Lung Injury Induced by Intraperitoneal LPS.

References:

[1]. Liu L, Wang R, et,al. Procyanidin B2 ameliorates endothelial dysfunction and impaired angiogenesis via the Nrf2/PPARγ/sFlt-1 axis in preeclampsia. Pharmacol Res. 2022 Mar;177:106127. doi: 10.1016/j.phrs.2022.106127. Epub 2022 Feb 10. PMID: 35150862.

[2]. Kim GO, Park DH, et,al.Procyanidin B2 Attenuates Sepsis-Induced Acute Lung Injury via Regulating Hippo/Rho/PI3K/NF-κB Signaling Pathway. Int J Mol Sci. 2023 Apr 27;24(9):7930. doi: 10.3390/ijms24097930. PMID: 37175637; PMCID: PMC10177954.

وثائق المنتج (Product Documents)

Purity:>98.00%Appearance:A solid
COASDSData Sheet

الخصائص الكيميائية (Chemical Properties)

رقم CAS
29106-49-8
المرادفات
(-)-Epicatechin-(4β→8)-(-)-epicatechin, Proanthocyanidin B2, Procyanidol B2
الاسم الكيميائي
(2R,3R)-2-(3,4-dihydroxyphenyl)-8-[(2R,3R,4R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-4-yl]-3,4-dihydro-2H-chromene-3,5,7-triol
SMILES
C1C(C(OC2=C1C(=CC(=C2C3C(C(OC4=CC(=CC(=C34)O)O)C5=CC(=C(C=C5)O)O)O)O)O)C6=CC(=C(C=C6)O)O)O
الصيغة الجزيئية
C30H26O12
الوزن الجزيئي
578.52
الذوبانية
DMF: 30 mg/mL,DMSO: 30 mg/mL,Ethanol: 30 mg/mL,PBS (pH 7.2): 10 mg/mL
التخزين
Store at -20℃
إرشادات عامة
اختر مذيبًا مناسبًا وفقًا لبيانات ذوبانية المنتج. بعد التحضير، قسّم المحلول المخزون إلى أجزاء لتجنب دورات التجميد والذوبان المتكررة.
استخدم المحاليل المخزونة خلال 6 أشهر عند حفظها في -80°C، أو خلال شهر واحد عند حفظها في -20°C.
لتحسين الذوبانية، سخّن الأنبوب إلى 37°C وعرّضه للموجات فوق الصوتية لمدة مناسبة.
شروط الشحن
تُشحن عينات التقييم مع عبوات تبريد. وتُشحن الأحجام الأخرى المتاحة في درجة حرارة الغرفة، أو مع عبوات تبريد عند الطلب.

الحاسبات (Calculators)المولارية / التخفيف / الوزن الجزيئي / تحويل الوحدات / تركيبة داخل الجسم الحي / الذوبانية

g/mol

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