GLPBio

Reactive Oxygen Species

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Reactive oxygen species (ROS), such as superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•), consist of radical and non-radical oxygen species formed by the partial reduction of oxygen. Cellular ROS are generated endogenously during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion.

ROS also activates MAPK pathways by the direct inhibition of MAPK phosphatases. Through PTEN, the PI3K pathway is subject to reversible redox regulation by ROS generated by growth factor stimulation. The activation of autophagy may be a cellular defense mechanism in response to ROS.

Products Related to Reactive Oxygen Species(505)

  • GC81556 structure
    GC81556FZ1 peptide
    Purity: >99.50%

    FZ1 peptide is a cyclic heptapeptide and also an integrin αvβ3 agonist.

  • GC81568 structure
    GC81568M464
    Purity: >99.50%

    M464, a non-steroidal anti-inflammatory compound, is a potent and orally active NLRP3 inflammasome inhibitor.

  • GC81572 structure
    GC81572Glutathione trisulfide TFA
    Purity: >99.00%

    Glutathione trisulfide TFA (GSSSG TFA) is an orally active, blood-brain barrier permeable neuroprotective agent.

  • GC81573 structure
    GC81573Indigoidine
    CAS: 2435-59-8
    Purity: >98%

    Indigoidine is a natural biological pigment that appears in a bright blue color and is a natural blue dye with industrial applications.

  • GC81574 structure
    GC81574Hydroxyproline
    CAS: 6912-67-0
    Purity: >98.00%

    Hydroxyproline (DL-Hydroxyproline) is a non-essential amino acid and one of the main components of collagenous tissues.

  • GC81575 structure
    GC81575ZIP14-IN-1
    CAS: 1048-17-5
    Purity: >99.50%

    ZIP 14-IN-1 (PPTD) is a selective and orally active ZIP14 inhibitor.

  • GC81576 structure
    GC81576USF 2550A
    CAS: 5192-62-1
    Purity: >98%

    USF 2550A is a class of fungus-derived 2-pyran compound with DPPH free radical scavenging activity.

  • GC81577 structure
    GC81577Mono N-desmethyl disperse polyester dark blue
    CAS: 56524-77-7
    Purity: >98%

    Mono N-Desmethyl Disperse Polyester Dark Blue is a bioreductive agent that is activated under hypoxic conditions.

  • GC81578 structure
    GC81578Disperse polyester dark blue
    CAS: 56524-76-6
    Purity: >98%

    Disperse Polyester Dark Blue is a chemical compound extensively employed in scientific research.

  • GC81579 structure
    GC81579Ophthalmic acid TFA
    Purity: >98.00%

    Ophthalmic acid TFA is a ubiquitous metabolite and glutathione modulator, with a K i of 0.95 mM for glyoxalase I.

  • GC81580 structure
    GC81580MiADMSA
    CAS: 142609-62-9
    Purity: >98%

    MiADMSA (Monoisoamyl meso-2,3-dimercaptosuccinic acid) is an orally active thiol chelator that can effectively remove heavy metals such as arsenic and lead from the body of animals.

  • GC81583 structure
    GC81583HCM-01
    CAS: 2117631-52-2
    Purity: >99.00%

    HCM-01 is an Excitatory amino acid transporter 2 ( EAAT2 ) activator with oral effectiveness and blood-brain barrier penetration.HCM-01 binds to the allosteric site of EAAT2, increases EAAT2 expression in astrocytes, enhances glutamate-handling capacity, and modulates glutamate homeostasis.HCM-01 acts as an antioxidant, improves oxidative/antioxidative balance and increases total antioxidant capacity.

  • GC81584 structure
    GC815842-Amino-2-deoxy-D-glucopyranose
    CAS: 90-77-7
    Purity: >98.00%

    2-Amino-2-deoxy-D-glucopyranose is an isomeric form of Glucosamine.

  • GC81595 structure
    GC81595BCS12
    CAS: 329719-71-3
    Purity: >99.50%

    BCS12 is a CAIX inhibitor.

  • GC81596 structure
    GC81596SHMT2-IN-1
    Purity: >99.50%

    SHMT2-IN-1 is a potent serine hydroxymethyltransferase 2 ( SHMT2 ) inhibitor with an IC 50 of 1.21 μM and a K D of 10.6 μM.

  • GC81601 structure
    GC816012-Hydroxymelatonin
    CAS: 229018-17-1
    Purity: >98.00%

    2-Hydroxymelatonin is a major hydroxylated metabolite of Melatonin.

  • GC81602 structure
    GC81602Glucosamine sulfate potassium chloride
    CAS: 1296149-08-0
    Purity: >98.00%

    Glucosamine sulfate potassium chloride is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement.

  • GC81603 structure
    GC816034’-Phosphopantetheine
    CAS: 2226-71-3
    Purity: >97.50%

    4’-Phosphopantetheine is an orally active coenzyme A (CoA) precursor.

  • GC81606 structure
    GC81606DX-8951 Hydroxy-acid sodium
    Purity: >98.50%

    DX-8951 Hydroxy-acid sodium is a prodrug of phosphoramide.

  • GC81609 structure
    GC81609YHV98-4
    CAS: 132858-26-5
    Purity: >98.00%

    YHV98-4 is a selective, blood-brain barrier-permeable Hv1 inhibitor with an IC 50 of 0.7 μM.

  • GC81610 structure
    GC81610SK-129
    CAS: 1919889-97-6
    Purity: >98%

    SK-129 is a blood-brain barrier-permeable inhibitor of α-synuclein ( αS ) oligomers with a K d of 221 nM.

  • GC81611 structure
    GC81611Nrf2-IN-4 hydrobromide
    Purity: >99.00%

    Nrf2-IN-4 (Compound PhcY) hydrobromide is a Nrf2 inhibitor.

  • GC81618 structure
    GC81618Urolithin A- 13 C 6
    Purity: >99.50%

    Urolithin A - 13 C 6 is the 13 C-labeled Urolithin A.

  • GC81626 structure
    GC816264-Methoxyestradiol-d 5
    Purity: >98%

    4-Methoxyestradiol -d 5 is the deuterium labeled 4-Methoxyestradiol.