Obesity, Appetite Control & Diabetes

Ghrelin is an endogenous gastrointestinal hormone and neuropeptide that binds to the growth hormone (GH) secretagogue receptor (GHS-R).

GLP-1 (7-36) amide is a peptide hormone released from intestinal L-cells upon nutrient consumption.

Glucagon-like peptide-1 (GLP-1) (7-37) is an endogenous incretin hormone and truncated form of GLP-1 (1-37) that is produced via cleavage of preproglucagon in the pancreas and intestine.

Glucagon-like peptide-2 (GLP-2) is an endogenous peptide hormone formed in L cells of the small and large intestine by cleavage of proglucagon in response to nutrient ingestion.

An inactive control for glucagon receptor antagonist I

Glucocerebrosides are formed by the tethering of glucose to a ceramide by glucosylceramide synthase.

Glyburide is a sulfonylurea and an inhibitor of sulfonylurea receptor 1 (SUR1) linked to ATP-sensitive potassium channel Kir6.2 (IC50 = 4.3 nM).

صيغة الحمض المراري الثانوي ليتوكوليك مرتبط بالجلاسين.

Glycolithocholic acid is a glycine conjugate of lithocholic acid, a bile acid.

GW9578 هو ناهض PPARα انتقائي من النوع الفرعي (EC50s من 5 و 50 نانومتر للفئران والبشر PPAR-α) مع نشاط فعال لخفض الدهون

Fasudil (HA-1077؛ AT877) ثنائي هيدروكلوريد هو مثبط RhoA / ROCK غير محدد وله أيضًا تأثير مثبط على كينازات البروتين ، مع Ki 0.33 μ ؛ M لـ ROCK1 ، IC50s من 0.158 μ ؛ M و 4.58 &8888956 ؛ M و 4.58 &8888956 ؛ ؛ M ، 1.650 μ ؛ M لـ ROCK2 و PKA ، PKC ، PKG ، على التوالي. HA-1077 (هيدروكلوريد) هو أيضًا مضاد فعال لقناة Ca2+ وموسع للأوعية.

Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor that stimulates food intake and transduces signals to hypothalamic regulatory nuclei that control energy homeostasis.

Lactisole is a canonical antagonist of sweet taste receptor, selectively targeting to T1R3 subunit.

Lithocholic acid 3-sulfate is a metabolite of the secondary bile acid lithocholic acid.

MHY908 هو ناهض مزدوج قوي لـ PPARα و PPARγ

ML-262 is an inhibitor of hepatic lipid droplet formation (IC50 = 6.4 nM in murine AML-12 cells), which is associated with non-alcoholic fatty liver disease.

MLS-0322825 Cmpd 23 هو مثبط انتقائي لبروتين التيروزين فوسفاتيز منخفض الوزن الجزيئي (LMPTP) ، مع IC50 من 0.8 μ ؛ M LMPTP-A.

Agmatine is a natural polyamine formed by the enzymatic decarboxylation of arginine.

ND-336 هو مثبط انتقائي لمصفوفة metalloproteinase (MMP) -2 و MMP-9 و MMP-14 ، مع Kis من 85 و 150 و 120 نانومتر ، على التوالي

Neuromedin S is a neuropeptide expressed in brain.

N-Oleoyl Leucine is a fatty acid–amino acid conjugate (FAAA) that belongs to the family of N-acyl amino acids.

O-7460 هو مثبط قوي وانتقائي DAGLα ، مع IC50 0.69 ميكرومتر

Obestatin is a 23-amino acid peptide hormone that is formed by cleavage of the ghrelin and obestatin prepropeptide.

Orlistat degradation product is a degradation product of the digestive lipase inhibitor orlistat.