GLP-1 (7-37) (human, bovine, guinea pig, mouse, rat) (trifluoroacetate salt) (Synonyms: Glucagon-like Peptide-1 (7-37) (human, bovine, guinea pig, mouse, rat)) |
| رقم الكتالوجGC43763 |
Glucagon-like peptide-1 (GLP-1) (7-37) is an endogenous incretin hormone and truncated form of GLP-1 (1-37) that is produced via cleavage of preproglucagon in the pancreas and intestine.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Glucagon-like peptide-1 (GLP-1) (7-37) is an endogenous incretin hormone and truncated form of GLP-1 (1-37) that is produced via cleavage of preproglucagon in the pancreas and intestine. It binds to βTC-1 and RIN 1027-B2 cells (Kds = 3.3 and 3.5 nM, respectively) and enhances insulin secretion in βTC-1 cells in a concentration- and glucose-dependent manner. Ex vivo, GLP-1 (7-37) stimulates insulin release from perfused rat pancreas. GLP-1 (7-37) increases plasma insulin concentrations by greater than 50% as compared to vehicle control in response to hyperglycemia in rats when administered at a dose of 15 pmol/min/kg for five days.
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