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DYRK

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Mammalian DYRKs are a subfamily of mitogen-activated protein kinase-related protein kinases and are originally discovered on the basis of homology to the Saccharomyces cerevisiae Yak1 and Drosophila mini-brain kinases. DYRKs possess Ser/Thr phosphorylation activity as well as autophosphorylation activity on Tyr residue(s).

Two isoforms of DYRK, DYRK1A and DYRK1B, co-immunoprecipitate with HAN11 when coexpressed in COS cells indicating that the proteins interact in mammalian cells. Co-expression of DYRK1A, DYRK1B, or DYRK2 with a series of glycogen synthase mutants with Ser/Ala substitutions at the phosphorylation sites in COS cells revealed that protein kinases cause phosphorylation of site 3a in glycogen synthase. Control of glycogen synthase by DYRK represents a novel mechanism, and a potentially novel pathway, for the regulation of glycogen synthesis.

Products Related to DYRK(38)

  • GC70625 structure
    GC70625AnnH31
    CAS: 241809-12-1
    Purity: >99.00%

    AnnH31 هو مثبط Dyrk1A (IC50: 81 نانومتر).

  • GC70985 structure
    GC70985Dyrk1A-IN-3
    CAS: 2493976-27-3
    Purity: >99.00%

    Dyrk1A-IN-3 (المركب 8b)، وهو مثبط كيناز 1A ثنائي النوعية عالي الانتقاء (DYRK1A)، يحافظ على مستويات عالية من ارتباط DYRK1A (IC50=76 نانومتر).

  • GC71197 structure
    GC71197FINDY
    CAS: 1507367-37-4

    FINDY هو مثبط انتقائي متوسط قابل للطي لـ DYRK1A.

  • GC72931 structure
    GC72931HTH-01-091 TFA
    Purity: >98.00%

    مثبط HTH-01-091 TFA هو مثبط فعال وانتقائي لسحابة الليوسين كيناز الأمومي (MELK)، مع IC50 من 10.5 نانومتر.

  • GC72982 structure
    GC72982BT173
    CAS: 2232180-74-2
    Purity: >98.00%

    يعتبر BT173 مثبط فعال لتفاعل المجال homeodomain للبروتين كيناز 2 (HIPK2).

  • GC73224 structure
    GC73224CLK1-IN-3
    CAS: 2922550-28-3
    Purity: >98.00%

    CLK1-IN-3 (المركب 10ad) هو مثبط قوي وانتقائي Clk1، مع IC50 من 5 نانومتر وأكثر من 300 مرة انتقائية ل Dyrk1A.

  • GC73707 structure
    GC73707ON 108600
    CAS: 1585246-23-6
    Purity: >99.00%

    يعتبر ON 108600 مثبط لـ CK2 (Casein Kinase2)/TNIK/DYRK1، مع IC50 لـ DYRK1A/DYRKB و DYRK2 و CK2α1/CK2α2 و TNIK من 0.016 ميكرومتر/0.007 ميكرومتر و 0.028 ميكرومتر و 0.05 ميكرومتر/0.005 ميكرومتر و 0.005 ميكرومتر على التوالي.

  • GC74165 structure
    GC741654-(Trifluoromethyl)aniline-d4
    CAS: 1219795-48-8
    Purity: >99.00%

    4-(Trifluoromethyl)aniline-d4 هو ديوتيريوم يحمل 4-Trifluorometlaniline.

  • GC74261 structure
    GC74261(R)-(+)-O-Demethylbuchenavianine
    CAS: 1364123-68-1
    Purity: >98.00%

    (R)-(+)-O-Demethylbuchenavianine هو مثبط للكيناز المعتمد على السايكلين CDK.

  • GC80874 structure
    GC80874ARN25699
    Purity: >98%

    ARN25699 is a kinase inhibitor with an IC 50 of 5.5 nM against GSK-3β, 2.2 nM against FYN-α, and 242.3 nM against DYRK1A, and it exhibits oral bioavailability.

  • GC81300 structure
    GC81300PROTAC DYRK2 degrader-2
    CAS: 3061366-74-0
    Purity: >98.00%

    PROTAC DYRK2 degrader-2 is a PROTAC DYRK2 degrader based on curcumin analog A3.

  • GC81307 structure
    GC81307DYRK2-IN-2
    CAS: 2416195-65-6
    Purity: >98%

    DYRK2-IN-2 (Compound C17) is a selective inhibitor of DYRK2, with its IC 50 value being 40.3 nM.

  • GC81308 structure
    GC81308DYRK2-IN-2 hydrochloride
    Purity: >98.00%

    DYRK2-IN-2 hydrochloride is a selective DYRK2 inhibitor with an IC 50 of 40.3 nM.

  • GC81309 structure
    GC81309AO-365/43472821
    CAS: 1081122-55-5
    Purity: >99.50%

    AO-365/43472821 is a selective, brain-penetrant Dual-specificity tyrosine phosphorylation-regulated kinase 1A ( DYRK1A ) inhibitor ( IC 50 = 0.29 μM) and shows a significant inhibitory effect on ( CDC-like kinase 1) CLK1 ( IC 50 = 0.08 μM).