Ubiquitination/ Proteasome

Cryptotanshinone is a natural compound extracted from the roots of Salvia miltiorrhiza Bunge, exhibiting antitumor activity by inhibiting Signal Transducer and Activator of Transcription 3 (STAT3) with an IC 50 value of 4.6μM.

Piceatannol (3,3′,4,5′-trans-trihydroxystilbene) is a naturally occurring hydroxylated analogue of resveratrol.

Eupatilin is a natural flavonoid compound with multiple biological activities. It is an agonist of peroxisome proliferator-activated receptor α (PPARα) and has anti-apoptotic, antioxidant, and anti-inflammatory effects.

Cucurbitacin B is a kind of tetracyclic triterpenoid compounds isolated from cucurbitaceae, and exhibits a wide range of biological activities.

Ecdysterone is a naturally occurring ecdysone that controls molting (feathering) and metamorphosis in arthropods.

Dihydromyricetin is a natural flavanonol isolated from A. grossedentata and H. dulcis that has antioxidant, antiproliferative, anti-apoptotic, and anti-alcohol intoxication properties.

Hesperidin, a flavonoid from the peel of navel orange, inhibits lipid peroxidation with an IC 50 value of 179.1μM.

Myricetin is a natural flavonoid commonly found in plants, possessing antioxidant, anti-inflammatory, and anti-tumor activities, and acts as a novel inhibitor of mitogen-activated protein kinase kinase (MEK1) and neoplastic transformation in JB6 P+ mouse epidermal cells.

Honokiol is a natural bisphenol chemical with multiple biological activities. It targets multiple signaling molecules and has effective antioxidant, anti-inflammatory, anti-angiogenic and anti-cancer activities. It also has broad-spectrum antibacterial and anti-human immunodeficiency virus (HIV) activities.