SDZ285428 is a CYP51 inhibitor. SDZ285428 inhibits Trypanosoma cruzi (TC) CYP51 with I/E2 <1 (5 min) and I/E2=9 (1 h). SDZ285428 inhibits Trypanosoma brucei (TB) CYP51 with I/E2 <1 (5 min) and I/E2=35 (1 h)[1].
Specific inhibition of protozoan CYP51 can potentially provide treatment for human trypanosomiases[1].
[1]. Lepesheva GI, et al. CYP51: A major drug target in the cytochrome P450 superfamily. Lipids. 2008 Dec;43(12):1117-25.