Remdesivir (GS-5734) (Synonyms: GS-5734) |
| رقم الكتالوجGC32223 |
ريمديسيفير (GS-5734)، وهو مشتق نوكليوزيدي له فعالية مضادة للفيروسات، يبلغ قدرته الحرجة EC50 3.3 μM، 4.7 μM، 32 μM، 3.7 μM و9.2 μM على التوالي بالنسبة لـ SARS-CoV-2 وأصنافها ألفا وبيتا وجاما ودلتا.
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Cas No.: 1809249-37-3
Sample solution is provided at 25 µL, 10mM.
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Remdesivir is a nucleoside analogue, with effective antiviral activity, with EC50s of 74 nM for ARS-CoV and MERS-CoV in HAE cells, and 30 nM for murine hepatitis virus in delayed brain tumor cells.
Remdesivir (GS-5734) is a potent antiviral agent. Remdesivir inhibits murine hepatitis virus (MHV) with an EC50 of 30 nM, and blocks SARS-CoV and MERS-CoV in HAE cells with EC50s of both 74 nM in HAE cells after treatment for 24 h[1].
References
[1]. Agostini ML, et al. Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease. MBio. 2018 Mar 6;9(2). pii: e00221-18.
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