Heparin sulfate antagonist. Inhibits heparin sulfate-mediated cell attachment in vitro. Maintains hESCs in a pluripotent state by reversible inhibition of glycan-growth factor interactions.
Schuksz et al (2008) Surfen, a small molecule antagonist of heparan sulfate. Proc.Natl.Acad.Sci.USA 105 13074 PMID:18725627 |Huang et al (2018) Small molecule antagonist of cell surface glycosaminoglycans restricts mouse embryonic stem cells in a pluripotent state. Stem Cells. 36 45 PMID:28984039