PI3K-IN-6 |
| رقم الكتالوجGC36908 |
PI3K-IN-6 (المركب 20 أ) هو مثبط 3-كيناز (PI3K) β / نشط عن طريق الفم وانتقائي للغاية ، مع قيم IC تبلغ 7.8 نانومتر / 5.3 نانومتر لـ PI3K β / δ ، على التوالييحتوي PI3K-IN-6 (المركب 20 أ) على الأورام التي تحتوي على أفضل علاج محتمل للفوسفاتيز والتنسن المتماثل (PTEN)
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1842380-77-1
Sample solution is provided at 25 µL, 10mM.
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PI3K-IN-6 (compound 20a) is an oral active and highly selective phosphoinositide 3-kinase (PI3K) β/δ inhibitor, with IC50 values of 7.8 nM/5.3 nM for PI3K β/δ, respectively. PI3K-IN-6 (compound 20a) has potential top treat phosphatase and tensin homolog (PTEN) feficient tumors[1]. PI3Kβ|7.8 nM (IC50)|PI3Kδ|5.3 nM (IC50)|PI3Kα|850 nM (IC50)
[1]. Perreault S, et al. Discovery of a Phosphoinositide 3-Kinase (PI3K) β/δ Inhibitor for the Treatment of Phosphatase and Tensin Homolog (PTEN) Deficient Tumors: Building PI3Kβ Potency in a PI3Kδ-Selective Template by Targeting Nonconserved Asp856. J Med Chem. 2017 Feb 23;60(4):1555-1567.
Average Rating: 5 (Based on Reviews and 11 reference(s) in Google Scholar.)
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