Tos-PEG4-t-butyl ester |
| رقم الكتالوجGC38867 |
Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) هو رابط PROTAC ، والذي يشير إلى تركيبة PEGيمكن استخدام Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) في تركيب سلسلة من PROTACs ، مثل BI-3663BI-3663 عبارة عن PTK2 / FAK PROTAC انتقائي للغاية ، مع روابط cereblon لاختطاف E3 ligases لتدهور PTK2 ، وتمنع PTK2 مع IC50 من 18 نانومتر
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Cas No.: 217817-01-1
Sample solution is provided at 25 µL, 10mM.
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Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) is a PROTAC linker, which refers to the PEG composition. Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) can be used in the synthesis of a series of PROTACs, such as BI-3663 . BI-3663 is a highly selective PTK2/FAK PROTAC, with cereblon ligands to hijack E3 ligases for PTK2 degradation, and inhibits PTK2 with an IC50 of 18 nM[1].
[1]. Popow J, et al. Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions. J Med Chem. 2019 Mar 14;62(5):2508-2520.
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