XL092 (Synonyms: XL092) |
| رقم الكتالوجGC62266 |
XL092 هو مثبط نشط عن طريق الفم ، ومانع ATP تنافسي لمستقبلات متعددة كينازات التيروزين (RTKs) بما في ذلك MET و VEGFR2 و AXL و MER ، مع IC50s في الاختبارات المستندة إلى الخلية 15 نانومتر ، 1.6 نانومتر ، 3.4 نانومتر ، 7.2 نانومتر على التوالييعرض XL092 نشاطًا مضادًا للورمXL092 لديه القدرة على أبحاث الأمراض والظروف التي تعتمد على الكيناز
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Cas No.: 2367004-54-2
Sample solution is provided at 25 µL, 10mM.
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XL092 is a potent inhibitor of the activity of Axl, Mer and C-Met kinase with IC50s of <10 nM, respectively. XL092 exhibits anti-tumor activity and has the potential for kinase-dependent diseases and conditions research[1].
XL092 (compound 8; 3 mg/kg; iv) has a T1/2 of 5.4 hours, a CL of 43 mL/hr•kg. XL092 (3 mg/kg; po) has a T1/2 of 7.1 hours and a Cmax of 11.4 μM for rats[1].
[1]. Lynne Canne Bannen, et al. Compounds for the treatment of kinase-dependent disorders. WO2019148044A1.
Average Rating: 5 (Based on Reviews and 37 reference(s) in Google Scholar.)
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