ATP citrate lyase
ACLY (ATP citrate lyase) catalyzes the synthesis of acetyl-CoA from citrate. It is a cytosolic enzyme that involved in fetal growth/development, tumor cell growth/survival and metabolic disorder etc.
Products Related to ATP citrate lyase (10)
- GC10884BMS-303141CAS: 943962-47-8Purity: >98.00%
BMS-303141 is a highly potent and cell-permeable ATP-citrate lyase (ACL) inhibitor with an IC 50 value of 0.13μM.
- GC316322-Furoic acid (Furan-2-carboxylic acid)CAS: 88-14-2Purity: >98.00%
2-Furoic acid (Furan-2-carboxylic acid) (Furan-2-carboxylic acid) is an organic compound produced through furfural oxidation.
- GC33760ETC-1002 (ESP-55016)CAS: 738606-46-7Purity: >98.00%
ETC-1002 (ESP-55016) is a novel, once-daily oral lipid-lowering agent that inhibits adenosine triphosphate citrate lyase (ACL), an enzyme in the cholesterol synthesis pathway, and leads to upregulation of low-density lipoprotein cholesterol (LDL) receptors with half life between 15 and 24h.
- GC38932NDI-091143CAS: 2375840-87-0Purity: >98.00%
NDI-091143 is a potent and high-affinity human ATP-citrate lyase (ACLY) inhibitor with an IC50 of 2.1 nM (ADP-Glo assay), a Ki of 7.0 nM and a Kd of 2.2 nM. NDI-091143 inhibits ACLY catalysis allosterically, by stabilizing large conformational changes in the citrate domain that indirectly block the binding and recognition of citrate.
- GC60919Hydroxycitric acid tripotassium hydrateCAS: 6100-05-6Purity: >98.00%
Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) is the major active ingredient of Garcinia cambogia.
- GC63570(-)-Hydroxycitric acid lactoneCAS: 27750-13-6Purity: >98%
(-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a popular weight loss food supplement.
- GC71452(-)-Hydroxycitric acidCAS: 27750-10-3Purity: >98.00%
(-)-Hydroxycitric acid (Garcinia acid) is the principal acid of fruit rinds of Garcinia cambogia.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC10884 | BMS-303141 | 943962-47-8 | >98.00% | |
BMS-303141 is a highly potent and cell-permeable ATP-citrate lyase (ACL) inhibitor with an IC 50 value of 0.13μM. | ||||
| GC16952 | SB 204990 | 154566-12-8 | >99.50% | |
SB 204990, a lactone prodrug, potently inhibits ATP citrate-lyase. | ||||
| GC31632 | 2-Furoic acid (Furan-2-carboxylic acid) | 88-14-2 | >98.00% | |
2-Furoic acid (Furan-2-carboxylic acid) (Furan-2-carboxylic acid) is an organic compound produced through furfural oxidation. | ||||
| GC33760 | ETC-1002 (ESP-55016) | 738606-46-7 | >98.00% | |
ETC-1002 (ESP-55016) is a novel, once-daily oral lipid-lowering agent that inhibits adenosine triphosphate citrate lyase (ACL), an enzyme in the cholesterol synthesis pathway, and leads to upregulation of low-density lipoprotein cholesterol (LDL) receptors with half life between 15 and 24h. | ||||
| GC38932 | NDI-091143 | 2375840-87-0 | >98.00% | |
NDI-091143 is a potent and high-affinity human ATP-citrate lyase (ACLY) inhibitor with an IC50 of 2.1 nM (ADP-Glo assay), a Ki of 7.0 nM and a Kd of 2.2 nM. NDI-091143 inhibits ACLY catalysis allosterically, by stabilizing large conformational changes in the citrate domain that indirectly block the binding and recognition of citrate. | ||||
| GC48923 | (±)-Hydroxycitric Acid | 6205-14-7 | - | |
A hydroxy derivative of citric acid | ||||
| GC60919 | Hydroxycitric acid tripotassium hydrate | 6100-05-6 | >98.00% | |
Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) is the major active ingredient of Garcinia cambogia. | ||||
| GC63570 | (-)-Hydroxycitric acid lactone | 27750-13-6 | >98% | |
(-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a popular weight loss food supplement. | ||||
| GC71452 | (-)-Hydroxycitric acid | 27750-10-3 | >98.00% | |
(-)-Hydroxycitric acid (Garcinia acid) is the principal acid of fruit rinds of Garcinia cambogia. | ||||
| GC79762 | BGT-002 | 2127387-94-2 | >99.00% | |
BGT-002 (326E) is an orally active dual ACLY inhibitor and PPARα agonist. | ||||