GLPBio

AVE5688

Catalog No.: GC31627Purity:>99.50%
COASDSData Sheet
AVE5688 is an inhibitor of glycogen phosphorylase (GP), with IC50s of 430 nM and 915 nM and Kds of 170 nM and 530 nM for rabbit muscle glycogen phosphorylase (rmGPb and rmGPa, respectively); AVE5688 can be used for the research of type 2 diabetes.

Products are for research use only. Not for human use. We do not sell to patients.

AVE5688
Cas No.: 613260-13-2
1mgIn Stock
$234.00
1
5mgIn Stock
$378.00
1
10mgIn Stock
$513.00
1
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Description

AVE5688 is an inhibitor of glycogen phosphorylase (GP), with IC50s of 430 nM and 915 nM and Kds of 170 nM and 530 nM for rabbit muscle glycogen phosphorylase (rmGPb and rmGPa, respectively); AVE5688 can be used for the research of type 2 diabetes.

AVE5688 is an inhibitor of glycogen phosphorylase (GP), with IC50s of 430 nM and 915 nM and Kds of 170 nM and 530 nM for rabbit muscle glycogen phosphorylase (rmGPb and rmGPa, respectively)[1].

[1]. Anderka O, et al. Thermodynamic characterization of allosteric glycogen phosphorylase inhibitors. Biochemistry. 2008 Apr 22;47(16):4683-91.

Protocol

Kinase experiment:

Glycogen phosphorylase activity is measured in the physiological direction of glycogen breakdown. rmGP is used for the kinetic characterization of the inhibitors (AVE5688). To routinely check the phosphorylation grade of enzyme batches, activity is measured in the direction of glycogen synthesis; the phosphorylation grade is estimated from the ratio of the activity in the presence of 0.5 mM caffeine to the activity in the presence of 2 mM AMP[1].

References:

[1]. Anderka O, et al. Thermodynamic characterization of allosteric glycogen phosphorylase inhibitors. Biochemistry. 2008 Apr 22;47(16):4683-91.

Product Documents

Purity:>99.50%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
613260-13-2
SMILES
O=C(O)C1=CC=C(NC(NC(C2=CC(F)=C(F)C=C2Cl)=O)=O)C(OC(F)(F)F)=C1
Molecular Formula
C16H8ClF5N2O5
Molecular Weight
438.69
Solubility
DMSO : 100 mg/mL (227.95 mM; Need ultrasonic)
Storage
Store at -20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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