β-Cyfluthrin (beta-Cyfluthrin) is a type II synthetic pyrethroid and also an active ingredient of many insecticide products used for pestsin agriculture. β-Cyfluthrin is a neurotoxicant and affects calcium concentration in nervous tissue by inhibiting Ca 2+ ATPase involved in calcium transport [1].
In Vivo, β-Cyfluthrin (20-40 mg/kg, po, once daily for 40 days) inhibits locomotor activity, impairs the learning ability, causes anxiety-like behaviors and growth retardation in mouse models[1].
In Vitro, β-Cyfluthrin (80 μM, 48 h) reduces the cell viability of primary rat hepatocytes, affects levels of intracellular malondialdehyde (MDA) and nitrate/nitrite, and decreases the activity of superoxide dismutase (SOD)[2].
References:
[1]. Neelu Kanwar Rajawat, et al. Effect of β-cyfluthrin (Synthetic Pyrethroid) on Learning, Muscular Coordination and Oxidative Stress in Swiss Albino Mice. Toxicol Ind Health. 2019 May;35(5):358-367.
[2]. Mousavi L, et al., β-Cyfluthrin-Mediated Cytotoxicity of Cultured Rat Primary Hepatocytes Ameliorated by Cotreatment with Luteolin. Evid Based Complement Alternat Med. 2022 Aug 27;2022:3647988.
In Vivo, β-Cyfluthrin (20-40 mg/kg, po, once daily for 40 days) inhibits locomotor activity, impairs the learning ability, causes anxiety-like behaviors and growth retardation in mouse models[1].
In Vitro, β-Cyfluthrin (80 μM, 48 h) reduces the cell viability of primary rat hepatocytes, affects levels of intracellular malondialdehyde (MDA) and nitrate/nitrite, and decreases the activity of superoxide dismutase (SOD)[2].
References:
[1]. Neelu Kanwar Rajawat, et al. Effect of β-cyfluthrin (Synthetic Pyrethroid) on Learning, Muscular Coordination and Oxidative Stress in Swiss Albino Mice. Toxicol Ind Health. 2019 May;35(5):358-367.
[2]. Mousavi L, et al., β-Cyfluthrin-Mediated Cytotoxicity of Cultured Rat Primary Hepatocytes Ameliorated by Cotreatment with Luteolin. Evid Based Complement Alternat Med. 2022 Aug 27;2022:3647988.