GLPBio

BAY 1892005

Catalog No.: GC73719Purity:>99.00%
COASDSData Sheet
BAY 1892005 is a regulator of p53 protein and acts on p53 condensates without causing mutant p53 reactivation.

Products are for research use only. Not for human use. We do not sell to patients.

BAY 1892005
Cas No.: 2036352-13-1
5 mgIn Stock
$252.00
1
10 mgIn Stock
$405.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citations

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  • Nature cover
    Nature
    641, 529–536 (2025)
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    Nature
    628, 630–638 (2024)
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    Nature
    632, 686–694 (2024)
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    Nature
    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
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    387(6739) (2025)
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    Science
    387(6734) (2025)
  • Cell Research cover
    Cell Research
    35, 97–116 (2025)
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    Cell Research
    34, 683–706 (2024)
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    Cell Research
    33, 273–287 (2023)
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    Cell Research
    33, 546–561 (2023)
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    Cell Research
    33, 904–922 (2023)
  • Cell Research cover
    Cell Research
    31, 1291–1307 (2021)

Description

BAY 1892005 is a regulator of p53 protein and acts on p53 condensates without causing mutant p53 reactivation.

BAY 1892005 inhibits cell proliferation in p53 mutated cell lines Huh7 (IC50=11.2 μM) and H358 (IC50=11.1 μM)[1].

References:
[1]. Lemos C, et al. Identification of Small Molecules that Modulate Mutant p53 Condensation[J].iScience, 2020, 23(9):101517.

Product Documents

Purity:>99.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
2036352-13-1
Molecular Formula
C11H8ClFN2OS
Molecular Weight
270.71
Solubility
DMSO : 250 mg/mL (923.50 mM; Need ultrasonic)
Storage
-20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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