GLPBio

BCRP

BCRP(breast cancer resistance protein), also called ABCG2 (ATP-binding cassette subfamily G member 2) is expressed in MDR (multi-drug resistance) diverse cancer cells. It protects cell from toxic xenobiotic substance in intestine, biliary tract, placenta, blood-testis barrier and blood-brain barriers.

Products Related to BCRP(15)

  • GC18163 structure
    GC18163YHO-13177
    CAS: 912287-56-0
    Purity: >98.00%

    A potent and specific inhibitor of BCRP

  • GC10874 structure
    GC10874Fumitremorgin C
    CAS: 118974-02-0
    Purity: >98.00%

    multidrug transporter inhibitor

  • GC12711 structure
    GC12711Ko 143
    CAS: 461054-93-3
    Purity: >98.00%

    Ko 143 is a potent and selective inhibitor of breast cancer resistance protein (BCRP; ABCG2) with an IC 50 value of 23nM.

  • GC14688 structure
    GC14688KS 176
    CAS: 1253452-78-6
    Purity: >98.00%

    inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter

  • GC17215 structure
    GC17215Elacridar
    CAS: 143664-11-3
    Purity: >98.00%

    An inhibitor of MRP-1 and BCRP

  • GC32114 structure
    GC32114YHO-13351
    CAS: 1346753-00-1
    Purity: >99.50%

    YHO-13351 is the prodrug of YHO-13177, which is a potent and specific inhibitor of BCRP.

  • GC32593 structure
    GC32593Zamicastat (BIA 5-1058)
    CAS: 1080028-80-3
    Purity: >98.00%

    Zamicastat (BIA 5-1058) (BIA 5-1058) is a dopamine β-hydroxylase (DBH) inhibitor and can cross the blood-brain barrier (BBB) to cause central as well as peripheral effects.

  • GC33056 structure
    GC33056YHO-13351 free base
    CAS: 912288-64-3
    Purity: >99.50%

    YHO-13351 free base is the prodrug of YHO-13177, which is a potent and specific inhibitor of BCRP.

  • GC33099 structure
    GC33099BCRP-IN-1
    CAS: 1699720-85-8
    Purity: >99.00%

    BCRP-IN-1 is a breast cancer resistance protein (BCRP) inhibitor with an IC50 of 0.6 μM on BCRP efflux transporter.

  • GC36034 structure
    GC36034FD 12-9
    CAS: 1451741-22-2
    Purity: >98%

    FD 12-9 is a flavonoid dimer, acts as a dual inhibitor of P-gp and BCRP, with EC50s of 285 nM and 0.9 nM, respectively. Anti-glioblastoma activity.

  • GC38129 structure
    GC38129ML753286
    CAS: 1699720-89-2
    Purity: >99.50%

    ML753286 is an orally active and selective BCRP (Breast cancer resistance protein) inhibitor with an IC50 of 0.6 μM. ML753286 has high permeability and low to medium clearance in rodent and human liver S9 fractions, and is stable in plasma cross species.

  • GC68596 structure
    GC68596Ac32Az19
    CAS: 2760674-72-2
    Purity: >98%

    Ac32Az19 is an effective, non-toxic, and highly selective BCRP inhibitor with an EC50 value of 13 nM in HEK293/R2 cells overexpressing BCRP.

  • GC69042 structure
    GC69042Efflux inhibitor-1
    CAS: 1776055-29-8
    Purity: >98.00%

    Efflux inhibitor-1 (compound 2) is a pyrazolo[1,5-a]pyrimidine efflux inhibitor. Efflux inhibitor-1 selectively targets ABCG2 over ABCB1 with IC50 values of 0.45 μM and 2.17 μM, respectively.

  • GC70762 structure
    GC70762Triclabendazole sulfoxide
    CAS: 100648-13-3
    Purity: >98.00%

    Triclabendazole sulfoxide (TCBZ-SO) is the main plasma metabolite of Triclabendazole, and exhibits anti-parasite effects.

  • GC81818 structure
    GC8181811β,13-Dihydrolactucopicrin
    CAS: 125519-47-3
    Purity: >98%

    11β,13-Dihydrolactucopicrin is a sesquiterpene lactone and the main bitter component of chicory root.