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Bicyclol

Catalog No.GC18304 Copy One-Click Copy Product Info

Bicyclol is a hepatoprotective agent.

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Bicyclol Chemical Structure

Cas No.: 118159-48-1

Size Price Stock Qty
1mg
$22.00
In stock
5mg
$56.00
In stock
10mg
$92.00
In stock

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Sample solution is provided at 25 µL, 10mM.



Description of Bicyclol

Bicyclol is a hepatoprotective agent.,,, It has antiviral activity against hepatitis B (HBV), reducing viral DNA and the secretion of the HBV antigens HBsAg and HBeAg by 59 and 35%, respectively, in infected 2.2.15 HepG2 cells. In vivo, bicyclol reduces duck HBV (DHBV) DNA in DHBV-infected ducks at doses >=0.4 g/kg. It also reduces the expression of TNF-α and the accumulation of lymphocytes in the liver in a mouse model of liver injury induced by concanavalin A . Oral administration of bicyclol prior to injection of diethylnitrosamine (DEN) and phenobarbital prevents formation of DEN/PB-induced hepatocellular carcinomas. It also reduces liver fibrosis in a rat model of bile duct ligation-induced hepatic fibrosis.

Chemical Properties of Bicyclol

Cas No. 118159-48-1 SDF
Chemical Name 5'-(hydroxymethyl)-7,7'-dimethoxy-[4,4'-bi-1,3-benzodioxole]-5-carboxylic acid, methyl ester
Canonical SMILES O=C(OC)C1=CC(OC)=C(OCO2)C2=C1C3=C(CO)C=C(OC)C4=C3OCO4
Formula C19H18O9 M.Wt 390.3
Solubility DMF: 25 mg/ml,DMSO: 25 mg/ml,DMSO:PBS (pH 7.2)(1:9): 0.1 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of Bicyclol

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.5621 mL 12.8107 mL 25.6213 mL
5 mM 512.4 μL 2.5621 mL 5.1243 mL
10 mM 256.2 μL 1.2811 mL 2.5621 mL
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In vivo Formulation Calculator (Clear solution) of Bicyclol

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

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Reviews

Review for Bicyclol

Average Rating: 5 ★★★★★ (Based on Reviews and 11 reference(s) in Google Scholar.)

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