Bicyclopyrone is an inhibitor of 4-hydroxyphenylpyruvate dioxygenase (Hpd) [1].
In Vitro, 4-hydroxyphenylpyruvate dioxygenase catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisate is the last step in the melanin biosynthesis pathway[1].
References:
[1]. María Elisa Pavan, et al. Glycerol inhibition of melanin biosynthesis in the environmental Aeromonas salmonicida 34mel T. Appl Microbiol Biotechnol. 2019 Feb;103(4):1865-1876.
In Vitro, 4-hydroxyphenylpyruvate dioxygenase catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisate is the last step in the melanin biosynthesis pathway[1].
References:
[1]. María Elisa Pavan, et al. Glycerol inhibition of melanin biosynthesis in the environmental Aeromonas salmonicida 34mel T. Appl Microbiol Biotechnol. 2019 Feb;103(4):1865-1876.
















