Metabolic Enzymes

N,S-Bis-Fmoc-glutathione is a competitive inhibitor of glyoxalase II with a K i value of 0.75μM and an IC 50 value of 2.5μM.

Z-Gly-Pro-pNA isa chromogenic substrate that can be cleaved by prolyl endopeptidases.

Acarbose is an oral α-glucosidase inhibitor (IC 50 = 11nM), which belongs to the class of oligosaccharide drugs.

UNC 3230 is a highly selective and ATP-competitive phosphatidylinositol 4-phosphate 5-kinase type 1C (PIP5K1C) inhibitor with an IC 50 value of 41nM.

Lomitapide is an inhibitor of microsomal triglyceride transfer protein (MTTP), with an IC 50 value of 8nM.

PCI-27483 is a reversible small-molecule activated factor VIIa (FVIIa) inhibitor.

SP-13786 is a potent and highly selective inhibitor of fibroblast activation protein (FAP) and prolyl oligopeptidase (PREP) (FAP: IC 50 = 3.2nM; PREP: IC 50 = 1.8μM).

2-(2-Phenylethyl)chromone is the main bioactive component of agarwood which showed diverse pharmaceutical activities, such as anti-inflammatory activity, anticancer activity, neuroprotective activity, antioxidant activity, acetylcholinesterase inhibition activity.

β-Glucuronidase from bovine liver is an important lysosomal enzyme involved in the degradation of glucuronic acid-containing glycosaminoglycans.

α-Amylase, heat-stable (BR, 40000u/g) is a thermostable α-amylase produced by fermentation and purification from Bacillus licheniformis .

LY 345899 is an inhibitor of methylenetetrahydrofolate dehydrogenase (MTHFD) 1 and MTHFD2, with an IC 50 value of 96 and 663nM, respectively.

OSMI-4 is a potent O-GlcNAc transferase (OGT) inhibitor, with an EC 50 value of 3μM.

ISA-2011B, a diketopiperazine fused C-1 indol-3-yl substituted tetra-hydro-isoquinoline, specifically inhibiting the PIP5Kα and the related AKT pathways.

RR6 is a potent, selective, reversible, competitive and orally active vanin inhibitor with an IC 50 of 540nM for recombinant vanin-1.

R162 is a potent inhibitor of glutamate dehydrogenase 1 (GDH1).

UDP-GlcNAc Disodium Salt is produced by the hexosamine biosynthesis pathway (HBP)and acts as a precursor for several important biomolecules like glycosaminoglycans, which is an essential substrate for protein glycosylation reactions in mammals.

DS18561882 is a novel, orally active, specific inhibitor of methylenetetrahydrofolate dehydrogenase (MTHFD2), exhibiting an IC 50 value of 0.0063 μM.

KYP 2047 is a potent, blood-brain barrier permeable prolyl oligopeptidase (POP; K i =0.023nM) inhibitor. By highly selectively inhibiting POP enzyme activity, KYP 2047 can modulate levels of neuropeptides in the brain that are associated with learning, memory, and neurodegenerative diseases.

DDAO is a near-infrared (NIR) red fluorescent probe with tunable excitation wavelength (600-650nm) and long emission wavelength (λem=656nm) and a relatively low pKa (~5).

UDP-GalNAz disodium (UDP-N-azidoacetylgalactosamine disodium) is an analog of UDP-GalNAc. UDP-GalNAc serves as a critical precursor for various glycosylation reactions and functions as a donor substrate for many N-acetylgalactosaminyltransferases, which transfer GalNAc from the nucleotide sugar to carbohydrate or peptide acceptors.

KHK-IN-2 is a highly potent and selective inhibitor of fructokinase (KHK) with an IC 50 of 0.45μM.

ACSS2-IN-2, also known as MTB-9655, is a potent inhibitor of acyl-CoA synthetase Short Chain Family Member 2 (ACSS2), with an IC 50 value of 0.15nM.

Vupanorsen (sodium) is an N-acetyl galactosamine-conjugated antisense oligonucleotide that inhibits Angiopoietin-like 3 (ANGPTL3) protein synthesis.

TH9619 is a potent inhibitor of dedrogenase and cyclodrolase activities in both MTHFD1 and MTHFD2 with a IC50 value of 47 nM, and selectively kills cancer cells.