GLPBio

BIO-2007817

Catalog No.: GC82421Purity:>99.00%
COASDSData Sheet
BIO-2007817 is a Parkin positive allosteric modulators (PAMs).

Products are for research use only. Not for human use. We do not sell to patients.

BIO-2007817
10mM (in 1mL DMSO)In Stock
$325.00
1
5mgIn Stock
$267.00
1
10mgIn Stock
$437.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citations

No citations are currently available for this product. Below are selected publications citing GlpBio products.
  • Nature cover
    Nature
    641, 529–536 (2025)
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    Nature
    628, 630–638 (2024)
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    Nature
    632, 686–694 (2024)
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    Nature
    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
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    Science
    387(6739) (2025)
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    Science
    387(6734) (2025)
  • Cell Research cover
    Cell Research
    35, 97–116 (2025)
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    Cell Research
    34, 683–706 (2024)
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    Cell Research
    33, 273–287 (2023)
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    Cell Research
    33, 546–561 (2023)
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    Cell Research
    33, 904–922 (2023)
  • Cell Research cover
    Cell Research
    31, 1291–1307 (2021)

Description

BIO-2007817 is a Parkin positive allosteric modulators (PAMs). BIO-2007817 enhances the activity of wildtype Parkin. BIO-2007817 stimulates Parkin (an E3 ligase )autoubiquitination and induces the appearance of monoubiquitinated forms of Miro1 (EC 50: 0.17 μM) [1].

References:
[1]. Shlevkov E, et al. Discovery of small-molecule positive allosteric modulators of Parkin E3 ligase. iScience. 2021 Dec 18;25(1):103650.

Product Documents

Purity:>99.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

Molecular Formula
C32H36N6O3
Molecular Weight
552.67
Solubility
DMSO: 50 mg/mL (90.47 mM; Need ultrasonic)
Storage
Store at -20°C
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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