BMS 986187 is a positive allosteric modulator of δ-opioid receptors. In the presence of the endogenous δ-opioid receptor agonist leu-enkephalin, BMS 986187 has an average EC50 value of 30 nM for β-arrestin recruitment, but has little to no activity in the absence of an agonist. It is 100-fold selective for δ- over u-opioid receptors in the presence of leu-enkephalin and the endogenous u-opioid receptor agonist endomorphin I, respectively.
BMS 986187
Catalog No.: GC18823
A positive allosteric modulator of δ-opioid receptors
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 684238-37-7
1mgIn Stock
$49.00
1
5mgIn Stock
$186.00
1
10mgIn Stock
$322.00
1
| Pack Size | Price | Availability | Quantity | Action |
|---|---|---|---|---|
| 1mg | $49.00 | In Stock | 1 | |
| 5mg | $186.00 | In Stock | 1 | |
| 10mg | $322.00 | In Stock | 1 |
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com
Citations
No citations are currently available for this product. Below are selected publications citing GlpBio products.
Nature641, 529–536 (2025)
Nature628, 630–638 (2024)
Nature632, 686–694 (2024)
Nature618, 1017–1023 (2023)
Nature610, 366–372 (2022)
Cell187(9):2288-2304 (2024)
Cell183(7):1867-1883 (2020)
Science388(6745) (2025)
Science387(6739) (2025)
Science387(6734) (2025)
Cell Research35, 97–116 (2025)
Cell Research34, 683–706 (2024)
Cell Research33, 273–287 (2023)
Cell Research33, 546–561 (2023)
Cell Research33, 904–922 (2023)
Cell Research31, 1291–1307 (2021)
Description
Product Documents
Appearance:A solid
Chemical Properties
CAS No.
684238-37-7
Chemical Name
3,4,5,6,7,9-hexahydro-3,3,6,6-tetramethyl-9-[4-[(2-methylphenyl)methoxy]phenyl]-1H-xanthene-1,8(2H)-dione
SMILES
CC1=C(COC2=CC=C(C3C(C(CC(C)(C)C4)=O)=C4OC(CC(C)(C)C5)=C3C5=O)C=C2)C=CC=C1
Molecular Formula
C31H34O4
Molecular Weight
470.6
Solubility
DMF: 1 mg/ml,DMF:PBS(pH7.2) (1:2): 0.33 mg/ml,DMSO: slightly soluble,Ethanol: slightly soluble
Storage
Store at -20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.
CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility
g/mol
Reviews
Review for BMS 986187
Rating: 5
- 5 Star100%
- 4 Star0%
- 3 Star0%
- 2 Star0%
- 1 Star0%