IC50: 0.6 nM (AAK1); 45 nM (BIKE); 60 nM (GAK)[1]
BMT-090605 hydrochloride is a potent, selective the adapter protein-2 associated kinase 1 (AAK1) inhibitor with an IC50 value of 0.6 nM. BMT-090605 hydrochloride shows antinociceptive activity. BMT-090605 hydrochloride inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50 values of 45 nM and 60 nM, respectively. BMT-090605 hydrochloride can be used for the research of neuropathic pain[1].
BMT-090605 hydrochloride shows AAK1inhibitory activity with an IC50 of 0.63 nM[1].
BMT-090605 hydrochloride inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50 values of 45 nM and 60 nM, respectively[1].
BMT-090605 hydrochloride(intrathecal; 0.3-3 µg/rat) causes antinociception by inhibiting AAK1 in the spinal cord[1].
| Animal Model: | Male Sprague-Dawley rats (chronic constriction injury (CCI) model)[1] |
| Dosage: | 0.3-3 µg/rat |
| Administration: | Intrathecal |
| Result: | Caused a dose-dependent reduction in thermal hyperalgesia. |