BMVC2 (o-BMVC) is a bisubstitute carbazole derivative of BMVC. BMVC2 is a G-quadruplex (G4) stabilizer[1].
BMVC2 by monitoring the disappearance of the 291 nm CD signals of d[AG3(T2AG3)3] (HT22) after adding Cu2+ is screened, a longer unfolding time would dictate a better G4 stabilizer. The unfolding curve of HT22 in the presence of BMVC2 can be fitted by using two time constants of 133.7 s (29%) and 2816 s (71%), which are similar to the unfolding parameters of BMVC[1].
[1]. Jen-Fei Chu, et al. A Novel Method for Screening G-quadruplex Stabilizers to Human Telomeres. Journal of the Chinese Chemical Society, 2011, 58, 296-300.