BMX Kinase
Bmx kinase is a member of Tec kinase family. It is involved in different signaling pathways and controls differential and tumorigenicity in several cancer types.
Products Related to BMX Kinase(3)
- GC33020CHMFL-BMX-078 (CHMFL-BMX 078)CAS: 1808288-51-8Purity: >98.00%
CHMFL-BMX-078 (CHMFL-BMX 078) is a highly potent and selective type II irreversible BMX kinase inhibitor with an IC50 of 11 nM.
- GC35684CHMFL-EGFR-202CAS: 2089381-40-6Purity: >98.00%
CHMFL-EGFR-202 is a potent, irreversible inhibitor of epidermal growth factor receptor (EGFR) mutant kinase, with IC50s of 5.3 nM and 8.3 nM for drug-resistant mutant EGFR T790M and WT EGFR kinases, respectively. CHMFL-EGFR-202 exhibits ?10-fold selectivity for EGFR L858R/T790M against the EGFR wild-type in cells. CHMFL-EGFR-202 adopts a covalent “DFG-in-C-helix-out” inactive binding conformation with EGFR, with strong antiproliferative effects against EGFR mutant-driven nonsmall-cell lung cancer (NSCLC) cell lines.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC11063 | BMX-IN-1 | 1431525-23-3 | >98.50% | |
A selective BMX and BTK inhibitor | ||||
| GC33020 | CHMFL-BMX-078 (CHMFL-BMX 078) | 1808288-51-8 | >98.00% | |
CHMFL-BMX-078 (CHMFL-BMX 078) is a highly potent and selective type II irreversible BMX kinase inhibitor with an IC50 of 11 nM. | ||||
| GC35684 | CHMFL-EGFR-202 | 2089381-40-6 | >98.00% | |
CHMFL-EGFR-202 is a potent, irreversible inhibitor of epidermal growth factor receptor (EGFR) mutant kinase, with IC50s of 5.3 nM and 8.3 nM for drug-resistant mutant EGFR T790M and WT EGFR kinases, respectively. CHMFL-EGFR-202 exhibits ?10-fold selectivity for EGFR L858R/T790M against the EGFR wild-type in cells. CHMFL-EGFR-202 adopts a covalent “DFG-in-C-helix-out” inactive binding conformation with EGFR, with strong antiproliferative effects against EGFR mutant-driven nonsmall-cell lung cancer (NSCLC) cell lines. | ||||