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Bombesin Receptors

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Bombesin, a peptide of 14 amino acids, is an amphibian homolog to the mammalian gastrin-releasing peptide (GRP), that has been extensively studied as a targeting ligand for diagnosis and therapy of GRP positive tumors, such as breast, pancreas, lungs and prostate cancers. Bombesin binds to and activates G-protein coupled receptors, known as gastrin releasing peptide receptor (GRPR).

Bombesin, a tetradecapeptide isolated from the skin of the frog Bombina bombina, have shown broad spectrum of biological activities. The BBS activates three G protein-coupled receptors: bombesin receptor 1 (BB1), bombesin receptor 2 (BB2), and bombesin receptor 3 (BB3). BBS-like peptides-Neuromedin B (NB) and gastrin releasing peptide (GRP) are natural ligand of the BB1 and BB2 receptors, respectively.

In mammals, BBS receptors and BBS-like peptides are distributed in the Central Nervous System (CNS) including regions involved in the cardiorespiratory control.

The mammalian bombesin G-protein-coupled receptor subfamily comprises three structurally related members, the receptors for neuromedin B (NMBR or BB1), gastrin-releasing peptide (GRPR or BB2), and bombesin receptor subtype-3 (BRS-3 or BB3).

Bombesin receptor subtype-3 (BRS-3) is an orphan G protein-coupled receptor implicated in the regulation of energy homeostasis.

Products Related to Bombesin Receptors(23)

  • GC11620 structure
    GC11620BIM 23127
    CAS: 160161-61-5
    Purity: >98%

    BIM 23127 is a highly selective agonist for somatostatin receptor subtype 2 (SSTR2) with a Ki value of 20.9nM.

  • GC12707 structure
    GC12707Neuromedin B (porcine)
    CAS: 87096-84-2
    Purity: >98.00%

    Neuromedin B (porcine) (NMB) is a member of Bombesin (BN)-like peptide family in mammals.

  • GC13768 structure
    GC13768PD 176252
    CAS: 204067-01-6
    Purity: >98.00%

    gastrin-releasing peptide receptor (GRP-R, BB2) and neuromedin B receptor (NMB-R, BB1) antagonist

  • GC14014 structure
    GC14014Bombesin
    CAS: 31362-50-2
    Purity: >99.50%

    Bombesin is a 14-amino acid peptide that belongs to the Bombesin-related peptide family and plays an important role in gastrin release and G protein receptor activation.

  • GC14279 structure
    GC14279BIM 189
    CAS: 142062-55-3
    Purity: >98%

    Bombesin antagonist

  • GC14662 structure
    GC14662Litorin
    CAS: 55749-97-8
    Purity: >98%

    Amphibian bombesin-like peptide

  • GC14908 structure
    GC14908Alytesin
    CAS: 31078-12-3
    Purity: >98%

    Amphibian bombesin-like peptide

  • GC15163 structure
    GC15163[D-Phe12]-Bombesin
    CAS: 108437-87-2
    Purity: >98%

    Bombesin receptor antagonist

  • GC15165 structure
    GC15165BIM 187
    CAS: 137734-88-4
    Purity: >98%

    Bombesin/GRP receptor agonist

  • GC16376 structure
    GC16376Neuromedin C (porcine)
    CAS: 81608-30-2
    Purity: >98.00%

    Mammalian bombesin-like neuropeptide

  • GC16415 structure
    GC16415Gastrin-Releasing Peptide (GRP) human
    CAS: 93755-85-2
    Purity: >98.00%

    GRP (human) (GRP) belongs to the bombesin-like peptide family, and is not a classical hypothalamic-hypophyseal regulatory hormone since it plays only a perfunctory role in the mediation of pituitary hormone release.

  • GC16854 structure
    GC16854GRP (porcine)
    CAS: 74815-57-9
    Purity: >98%

    agonist for the gastrin-releasing peptide receptor (GRPR)

  • GC17080 structure
    GC17080BIM 23042
    CAS: 111857-96-6
    Purity: >98%

    Antagonist of neuromedin B receptor,selective

  • GC17156 structure
    GC17156[D-Phe12,Leu14]-Bombesin
    CAS: 108437-88-3
    Purity: >98%

    Bombesin receptor antagonist

  • GC19413 structure
    GC19413MK-5046
    CAS: 1022152-70-0
    Purity: >99.00%

    MK-5046 is a potent, selective, and orally active Bombesin receptor subtype 3 (BRS-3) agonist, with IC 50 and EC 50 values of 27nM and 25nM, respectively, for human BRS-3.

  • GC33152 structure
    GC33152ML-18
    CAS: 1422269-30-4
    Purity: >98.50%

    A BB 3 receptor antagonist

  • GC36404 structure
    GC36404Kuwanon G
    CAS: 75629-19-5
    Purity: >98%

    Kuwanon G is a flavonoid isolated from Morus alba, acts as a bombesin receptor antagonist, with potential antimicrobial activity.

  • GC37072 structure
    GC37072RC-3095
    CAS: 138147-78-1
    Purity: >98%

    RC-3095 is a gastrin-releasing peptide (GRP) receptor antagonist.

  • GC38510 structure
    GC38510Kuwanon H
    CAS: 76472-87-2
    Purity: >98.50%

    eIF4A3-IN-8 is a selective ATP-competitive eukaryotic initiation factor 4A3 (eIF4A3) inhibitor. eIF4A3-IN-8 can serve as a valuable chemical probe to elucidate the detailed function of eIF4A3 and EJC (exon junction complex).

  • GC50215 structure
    GC50215BA 1
    CAS: 183241-31-8
    Purity: >98%

    Potent bombesin agonist

  • GC60619 structure
    GC60619BA 1 TFA
    Purity: >99.50%

    BA 1 TFA is a potent agonist for the bombesin (BB) family of receptors.

  • GC64112 structure
    GC64112RC-3095 TFA
    CAS: 1217463-61-0
    Purity: >97.00%

    RC-3095 TFA is a gastrin-releasing peptide (GRP) receptor antagonist.

  • GC70231 structure
    GC70231BIM 23042 TFA
    Purity: >96.00%

    BIM 23042 TFA, a certain somatostatin (SS) octapeptide analogue, is a selective neuropeptide neuromedin B receptor (NMB-R, BB1) antagonist.