C-178 |
| Catalog No.GC40570 |
C-178 is a covalent inhibitor of STING.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 329198-87-0
Sample solution is provided at 25 µL, 10mM.
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C-178 is a covalent inhibitor of STING. It binds to Cys91 on STING to block its palmitoylation and prevents recruitment and phosphorylation of TBK1 in HEK293T cells. C-178 (0.01-1.25 µM) selectively reduces STING-, but not RIG-I- or TBK1-, mediated IFN-β reporter activity in HEK293 cells. It also prevents increases in Ifnb1 expression in bone marrow-derived macrophages (BMDMs) induced by cyclic di-GMP , double-stranded DNA, and LPS when used at a concentration of 0.5 µM.
Average Rating: 5 (Based on Reviews and 1 reference(s) in Google Scholar.)
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