Platelet-type 12-lipoxygenase catalyzes the formation of 12-HpETE from arachidonic acid . It has been found to be expressed in various tumor cells as well as pancreatic islets and can be activated by inflammatory cytokines. It has also been implicated in the modulation of hemostasis and thrombosis through its role in regulating platelet function. CAY10698 is an inhibitor of 12-LO with an IC50 value of 5.1 µM. It demonstrates greatly reduced potency for 15-LO-1, 15-LO-2, and 5-LO (IC50s = >50, >40, and >200 µM. The scaffold of this compound has been subjected to medicinal chemistry optimization and biological characterization for development of potential 12-LO inhibitors.
CAY10698
Catalog No.: GC43194Purity:>98.00%
Platelet-type 12-lipoxygenase catalyzes the formation of 12-HpETE from arachidonic acid.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 684236-01-9
10mM (in 1mL DMSO)In Stock
$109.00
1
1mgIn Stock
$49.00
1
5mgIn Stock
$214.00
1
10mgIn Stock
$374.00
1
25mgIn Stock
$821.00
1
50mgIn Stock
$545.00
1
| Pack Size | Price | Availability | Quantity | Action |
|---|---|---|---|---|
| 10mM (in 1mL DMSO) | $109.00 | In Stock | 1 | |
| 1mg | $49.00 | In Stock | 1 | |
| 5mg | $214.00 | In Stock | 1 | |
| 10mg | $374.00 | In Stock | 1 | |
| 25mg | $821.00 | In Stock | 1 | |
| 50mg | $545.00 | In Stock | 1 |
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Citations
No citations are currently available for this product. Below are selected publications citing GlpBio products.
Nature641, 529–536 (2025)
Nature628, 630–638 (2024)
Nature632, 686–694 (2024)
Nature618, 1017–1023 (2023)
Nature610, 366–372 (2022)
Cell187(9):2288-2304 (2024)
Cell183(7):1867-1883 (2020)
Science388(6745) (2025)
Science387(6739) (2025)
Science387(6734) (2025)
Cell Research35, 97–116 (2025)
Cell Research34, 683–706 (2024)
Cell Research33, 273–287 (2023)
Cell Research33, 546–561 (2023)
Cell Research33, 904–922 (2023)
Cell Research31, 1291–1307 (2021)
Description
Product Documents
Purity:>98.00%Appearance:A solid
Chemical Properties
CAS No.
684236-01-9
SMILES
COC1=C(O)C(CNC2=CC=C(S(NC3=NC=CS3)(=O)=O)C=C2)=CC=C1
Molecular Formula
C17H17N3O4S2
Molecular Weight
391.5
Solubility
DMF: 25 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 20 mg/ml,Ethanol: 0.5 mg/ml
Storage
4°C, protect from light
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.
CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility
g/mol
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