Chlorotoluron

Chlorotoluron is a phenylurea herbicide that has been used to control growth of broad-leaved weeds in winter wheat, rye, barley, and triticale crops. It is genotoxic, inducing formation of chromosome aberrations and sister chromatid exchange (SCE) in a concentration-dependent manner in CHEL liver epithelial cells. Chlorotoluron (625-5,000 mg/kg) induces testicular anaplasia as well as looseness and incrassation to the basement membrane that destroys the blood-testis barrier, increases superoxide dismutase (SOD) activity, and degrades mitochondria in mice. It reduces food intake and body weight and induces hemolytic anemia, hemosiderosis of the spleen, and brown atrophy in dogs when administered at a dose of 9,200 ppm.