GLPBio

Chlorotoxin (trifluoroacetate salt)

Catalog No.: GC92127Purity:>95.00%Synonyms: CTX; TM-601
COASDSData Sheet
Chlorotoxin is a peptide originally isolated from the venom of the scorpion L. quinquestriatus.

Products are for research use only. Not for human use. We do not sell to patients.

Chlorotoxin (trifluoroacetate salt)
100µgIn Stock
$140.00
1
500µgIn Stock
$360.00
1
1 mgIn Stock
$576.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citations

No citations are currently available for this product. Below are selected publications citing GlpBio products.
  • Nature cover
    Nature
    641, 529–536 (2025)
  • Nature cover
    Nature
    628, 630–638 (2024)
  • Nature cover
    Nature
    632, 686–694 (2024)
  • Nature cover
    Nature
    618, 1017–1023 (2023)
  • Nature cover
    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
  • Science cover
    Science
    387(6739) (2025)
  • Science cover
    Science
    387(6734) (2025)
  • Cell Research cover
    Cell Research
    35, 97–116 (2025)
  • Cell Research cover
    Cell Research
    34, 683–706 (2024)
  • Cell Research cover
    Cell Research
    33, 273–287 (2023)
  • Cell Research cover
    Cell Research
    33, 546–561 (2023)
  • Cell Research cover
    Cell Research
    33, 904–922 (2023)
  • Cell Research cover
    Cell Research
    31, 1291–1307 (2021)

Description

Chlorotoxin is a peptide originally isolated from the venom of the scorpion L. quinquestriatus.1,2 It inhibits chloride currents in rat colonic enterocyte plasma membrane preparations when used at a concentration of 594 nM.1 Chlorotoxin also binds to, but does not inhibit, matrix metalloproteinase-2 (MMP-2; IC50s = 0.71 and >30 ?M, respectively), as well as neuropilin-1 (NRP-1; IC50 = 0.78 ?M) in cell-free assays.3 It induces paralysis in crayfish (P. clarkii) but is not cytotoxic to human U87MG glioma, MCF-7 breast cancer, PC3 prostate cancer, and A549 lung cancer cells.1,2 Administration of chimeric antigen receptor (CAR) T cells expressing CAR with chlorotoxin as the targeting domain increase survival and decrease tumor volume in an orthotopic patient-derived xenograft (PDX) mouse model of glioblastoma.4 Liposomes containing chlorotoxin and encapsulating doxorubicin decrease tumor volume in a U87 glioma mouse xenograft model.5 Fluorescently labeled chlorotoxin has been used for tumor imaging in vivo.6

References:
[1]. DeBin, J.A., Maggio, J.E., and Strichartz, G.R.Purification and characterization of chlorotoxin, a chloride channel ligand from the venom of the scorpionAm. J. Physiol.264(2 Pt 1)C361-C369(1993).
[2]. Ayed, A.S., Omran, M.A.A.A., Nabil, Z.I., et al.C-terminal amidation of chlorotoxin does not affect tumour cell proliferation and has no effect on toxin cytotoxicityInt. J. Pept. Res. Ther.27(1)659-667(2021).
[3]. Farkas, S., Cioca, D., Murányi, J., et al.Chlorotoxin binds to both matrix metalloproteinase 2 and neuropilin 1J. Biol. Chem.299(9)104998(2023).
[4]. Wang, D., Starr, R., Chang, W.C., et al.Chlorotoxin-directed CAR T cells for specific and effective targeting of glioblastomaSci. Transl. Med.12(533)eaaw2672(2020).
[5]. Xiang, Y., Liang, L., Wang, X., et al.Chloride channel-mediated brain glioma targeting of chlorotoxin-modified doxorubicine-loaded liposomesJ. Control Release152(3)402-410(2011).
[6]. Veiseh, M., Gabikian, P., Bahrami, S.B., et al.Tumor paint: A chlorotoxin:Cy.
[5]. 5 bioconjugate for intraoperative visualization of cancer fociCancer Res.67(14)6882-6888(2007).

Product Documents

Purity:>95.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

Synonyms
CTX; TM-601
Chemical Name
L-methionyl-L-cysteinyl-L-methionyl-L-prolyl-L-cysteinyl-L-phenylalanyl-L-threonyl-L-threonyl-L-α-aspartyl-L-histidyl-L-glutaminyl-L-methionyl-L-alanyl-L-arginyl-L-lysyl-L-cysteinyl-L-α-aspartyl-L-α-aspartyl-L-cysteinyl-L-cysteinylglycylglycyl-L-lysylglycyl-L-arginylglycyl-L-lysyl-L-cysteinyl-L-tyrosylglycyl-L-prolyl-L-glutaminyl-L-cysteinyl-L-leucyl-L-cysteinyl-L-argininamide, cyclic (2→19),(5→28),(16→33),(20→35)-tetrakis(disulfide), trifluoroacetate salt
SMILES
OC(C[C@H](NC([C@]([H])([C@@H](C)O)NC([C@]([H])([C@@H](C)O)NC([C@@H](NC([C@H]1NC([C@@H]2CCCN2C([C@H](CCSC)NC([C@H]3NC([C@H](CCSC)N[H])=O)=O)=O)=O)=O)CC4=CC=CC=C4)=O)=O)=O)C(N[C@@H](CC5=CNC=N5)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCSC)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN[H])C(N[C@@H]6C(N[C@@H](CC(O)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CSSC3)C(N[C@@H]7C(NCC(NCC(N[C@@H](CCCCN[H])C(NCC(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CCCCN[H])C(N[C@@H](CSSC1)C(N[C@@H](CC(C=C8)=CC=C8O)C(NCC(N9CCC[C@H]9C(N[C@@H](CCC(N)=O)C(N[C@@H](CSSC6)C(N[C@H](C(N[C@@H](CSSC7)C(N[C@@H](CCCNC(N)=N)C(N)=O)=O)=O)CC(C)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
Molecular Formula
C158H249N53O47S11 ? XCF3COOH
Molecular Weight
3995.7
Solubility
Water: Sparingly soluble: 1-10 mg/ml
Storage
-20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

Reviews

Review for Chlorotoxin (trifluoroacetate salt)

Rating: 5
  • 5 Star100%
  • 4 Star0%
  • 3 Star0%
  • 2 Star0%
  • 1 Star0%