Adaptive Immunity

An amino acid-containing building block

Calcium chelator

Cyclosporin A is an immunosuppressive agent which has three major cellular targets including cyclophilins, calcineurin and transporters while it can inhibit the activity of cyclophilin A and calcineurin with an IC 50 of 360nM and 5nM.

Study G protein-coupled receptor signaling in cells

Ferrichrome (iron-free) is a ferric ionophore for Ustilago sphaerogena , which can serve as a source of iron for the enzyme ferrochelatase.

1-Palmitoleoyl glycerol is a bioactive monoacylglycerol.

Cellocidin is an antibiotic originally isolated from S.

Acetyl-6-formylpterin is an inhibitor of mucosal-associated invariant T (MAIT) cell activation.

Galactosylcerebrosides are glycosphingolipids that contain a galactose attached to a ceramide acylated with hydroxy and non-hydroxy fatty acids.

Phosphatidylserine is a naturally occurring phospholipid that comprises 2-10% of total phospholipids in mammals and is enriched in the central nervous system, particularly the retina.

Concanavalin A belongs to the concanamycins, a family of macrolide antibiotics isolated from Streptomyces diastatochromogenes that are highly active and selective inhibitors of the vacuolar proton-ATPase (v-[H[+]]ATPase).

Bisindolylmaleimide XI (BIM XI) is a selective, cell-permeable protein kinase C (PKC) inhibitor that displays 10-fold greater selectivity for PKCα (IC50 = 9 nM) and 4-fold greater selectivity for PKCβI (IC50 = 28 nM) over Ca2+-independent PKCε (IC50 = 108 nM).

16,16-dimethyl PGA1 is a metabolism resistant analog of PGA1.

NIBR0213 is an orally bioavailable, potent, and selective antagonist of sphingosine-1-phosphate receptor-1 (S1P1) with IC50 values of 2.5 and 2.0 nM for the hS1P1 in a Ca2+ mobilization assay and GTPγS assay, respectively.

(S)-Indoximod (1-Methyl-L-tryptophan) is a novel, orally active IDO Pathway inhibitor (K i =19μM).

ALC-0315 is a key component of the COVID‐19mRNA vaccine and a highly sought-after lipid for nucleic acid therapeutics research .

(±)-Pinocembrin ((±)-5,7-Dihydroxyflavanone) is a GPR120 ligand able to promote wound healing in HaCaT cell line.

CYM5442 is a potent, highly-selective and orally active sphingosine 1-phosphate (S1P1) receptor agonist with an EC50 of 1.35 nM.

Ginsenoside CK, a secondary ginsenoside biotransformed from major ginsenosides, is more bioavailable and soluble than its parent ginsenosides and holds great significance.

Concanavalin ACon A, derived from Canavalia ensiformis beans, is a lectin protein (Mw 104 kDa).

Drimentine B is a terpenylated diketopiperazine antibiotic originally isolated from Actinomycete bacteria.

Z-VA-DL-D(OMe)-FMK (Z-VAD-FMK) is a pan-caspase inhibitor.