GLPBio

CPPA-TPP

Catalog No.: GC91800Purity:>75.00%Synonyms: CPPA-Triphenylphosphonium,4-Cyano-4-(phenylcarbonothioylthio)pentanoic Acid-TPP,4-Cyano-4-(phenylcarbonothioylthio)pentanoic-Triphenylphosphonium
COASDSData Sheet
CPPA-TPP is a chain transfer agent conjugated to the mitochondria-targeting moiety triphenylphosphonium (TPP).

Products are for research use only. Not for human use. We do not sell to patients.

CPPA-TPP
Cas No.: N/A
1 mgIn Stock
$69.00
1
5 mgIn Stock
$326.00
1
10 mgIn Stock
$617.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citations

No citations are currently available for this product. Below are selected publications citing GlpBio products.
  • Nature cover
    Nature
    641, 529–536 (2025)
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    628, 630–638 (2024)
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    Nature
    632, 686–694 (2024)
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    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
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    Science
    388(6745) (2025)
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    387(6739) (2025)
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    Science
    387(6734) (2025)
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    Cell Research
    35, 97–116 (2025)
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    34, 683–706 (2024)
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    33, 273–287 (2023)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    Cell Research
    31, 1291–1307 (2021)

Description

CPPA-TPP is a chain transfer agent conjugated to the mitochondria-targeting moiety triphenylphosphonium (TPP).1 It has been used in the synthesis of reactive oxygen species-sensitive mitochondrial targeting polyprodrugs containing the topoisomerase I inhibitor camptothecin.

References:
[1].Zhang, W., Hu, X., Shen, Q., et al.Mitochondria-specific drug release and reactive oxygen species burst induced by polyprodrug nanoreactors can enhance chemotherapyNat. Commun.10(1)1704(2019).

Product Documents

Purity:>75.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
N/A
Synonyms
CPPA-Triphenylphosphonium,4-Cyano-4-(phenylcarbonothioylthio)pentanoic Acid-TPP,4-Cyano-4-(phenylcarbonothioylthio)pentanoic-Triphenylphosphonium
Molecular Formula
C33H31NO2PS2•Br
Molecular Weight
648.6
Solubility
DMSO: Sparingly soluble: 1-10 mg/mL,Ethanol: Sparingly soluble: 1-10 mg/mL,PBS (pH 7.2): Slightly soluble:0.1-1 mg/mL
Storage
-20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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