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CRAC Channel

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The Ca2+ release-activated Ca2+ (CRAC) channel is a highly Ca2+-selective store-operated channel expressed in T cells, mast cells, and various other tissues. CRAC channels regulate critical cellular processes such as gene expression, motility, and the secretion of inflammatory mediators. The identification of Orai1, a key subunit of the CRAC channel pore, and STIM1, the endoplasmic reticulum (ER) Ca2+ sensor, have provided the tools to illuminate the mechanisms of regulation and the pore properties of CRAC channels. Opening of CRAC channels enables the refilling of ER Ca2+ stores and sustains long-lasting Ca2+ oscillations and plateau signals, critical for the proliferation of T cells and production of cytokines following antigenic stimulation.

Products Related to CRAC Channel(14)

  • GC11683 structure
    GC11683MRS 1845
    CAS: 544478-19-5
    Purity: >98.00%

    store-operated Ca2+ channels blocker

  • GC14665 structure
    GC14665YM 58483
    CAS: 223499-30-7
    Purity: >98.00%

    YM 58483 is a pyrazole-derived inhibitor of CRAC channels that inhibits Ca 2+ signals with an IC 50 value of 100nM.

  • GC19107 structure
    GC19107CM-4620
    CAS: 1713240-67-5
    Purity: >98.00%

    CM-4620 is a selective inhibitor of Orai channels, with IC 50 =0.119μM for Orai1 and 0.895μM for Orai2.

  • GC30361 structure
    GC30361CRAC intermediate 2
    CAS: 123066-64-8
    Purity: >99.50%

    CRAC intermediate 2 is a intermediate compound for CRAC inhibitor synthesis, extracted from patent WO 2013059666A1.

  • GC31680 structure
    GC31680GSK-5498A
    CAS: 1253186-49-0
    Purity: >98.00%

    GSK-5498A is a selective CARC channel inhibitor (IC50: 1 μM).

  • GC31852 structure
    GC31852CRAC intermediate 1
    CAS: 1249343-86-9
    Purity: >98.00%

    CRAC intermediate 1 is a key intermediate in the chemical synthesis of a series of CRAC channel inhibitors, detailed information can be found in Patent WO 2010122089 A1, intermediate 9.

  • GC33472 structure
    GC33472Synta66
    CAS: 835904-51-3
    Purity: >99.00%

    Synta66 is an inhibitor of store-operated calcium entry channel Orai, which forms the pore of the CRAC channel, and used for the research of neurological disease.

  • GC37658 structure
    GC37658SOCE inhibitor 1
    CAS: 2169316-15-6
    Purity: >99.50%

    SOCE inhibitor 1 is a store-operated calcium entry (SOCE) inhibitor with an IC50 of 4.4 μM.

  • GC50179 structure
    GC501795J 4
    CAS: 827001-82-1
    Purity: >98%

    CRAC channel blocker; anti-inflammatory

  • GC60327 structure
    GC60327RO2959 hydrochloride
    CAS: 1219927-22-6
    Purity: >98%

    RO2959 hydrochloride is a potent and selective CRAC channel inhibitor with an IC50 of 402 nM.

  • GC61248 structure
    GC61248RO2959 monohydrochloride
    CAS: 2309172-44-7
    Purity: >99.00%

    RO2959 monohydrochloride is a potent and selective CRAC channel inhibitor with an IC50 of 402 nM.

  • GC65999 structure
    GC65999piCRAC-1
    CAS: 2418049-54-2
    Purity: >98%

    piCRAC-1 is a potent, photoinducible Ca2+ release-activated Ca2+ (CRAC) channel inhibitor. piCRAC-1 alleviates thrombocytopenia and hemorrhage.

  • GC79519 structure
    GC79519SKF-96365
    CAS: 162849-90-3
    Purity: >99.50%

    SKF-96365 is a TRPC channel antagonist and store-operated calcium entry ( SOCE ) inhibitor.

  • GN10809 structure
    GN10809Tanshinone IIA sulfonate sodium
    CAS: 69659-80-9
    Purity: >98.00%