GLPBio

CTP354

Catalog No.: GC52077Purity:>99.00%
COASDSData Sheet
CTP354 is the deuterium labeled L-838417.

Products are for research use only. Not for human use. We do not sell to patients.

CTP354
Cas No.: 1213669-91-0
5 mgIn Stock
$98.00
1
10 mgIn Stock
$187.00
1
25 mgIn Stock
$370.00
1
50 mgIn Stock
$639.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citations

No citations are currently available for this product. Below are selected publications citing GlpBio products.
  • Nature cover
    Nature
    641, 529–536 (2025)
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    Nature
    628, 630–638 (2024)
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    Nature
    632, 686–694 (2024)
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    Nature
    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
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    Science
    387(6739) (2025)
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    Science
    387(6734) (2025)
  • Cell Research cover
    Cell Research
    35, 97–116 (2025)
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    Cell Research
    34, 683–706 (2024)
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    Cell Research
    33, 273–287 (2023)
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    Cell Research
    33, 546–561 (2023)
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    Cell Research
    33, 904–922 (2023)
  • Cell Research cover
    Cell Research
    31, 1291–1307 (2021)

Description

CTP354 is a deuterated derivative of the GABAA receptor modulator L-838,417.1 It binds to the GABAA receptor benzodiazepine binding site in non-α1 subunit-containing GABAA receptors. CTP354 has a longer duration of action than L-838,417 in a rat model of neuropathic pain induced by sciatic nerve ligation.

1.Harbeson, S.L., and Tung, R.D.Deuterium medicinal chemistry: A new approach to drug discovery and developmentMedchem News24(2)8-22(2014)

Product Documents

Purity:>99.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
1213669-91-0
SMILES
CN1C(COC2=NN3C(C4=C(C=CC(F)=C4)F)=NN=C3C=C2C(C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])=NC=N1
Molecular Formula
C19H10D9F2N7O
Molecular Weight
408.5
Solubility
DMF: 3 mg/ml,DMSO: 3 mg/ml,Ethanol: 2 mg/ml,PBS (pH 7.2): insol
Storage
-20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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