Pain Research

GW 405833 is a partial agonist of the cannabinoid CB2 receptor (EC50 = 0.65 nM).

Urocortin II is a neuropeptide hormone and member of the corticotropin-releasing factor (CRF) family which includes mammalian CRF , urocortin , urocortin III , frog sauvagine, and piscine urotensin I.

A selective inhibitor of COX-2

R-(-)-α-Methylhistamine (hydrochloride) is a potent, selective and brain-penetrant agonist of H3 histamine receptor, with a Kd of 50.3 nM.

N-Arachidonoyl Dopamine is a potent and selective endogenous CB1 receptor agonist with a Ki of 250 nM.

A metabolite of meloxicam

S-Adenosyl-L-methionine tosylate (S-Adenosyl methionine tosylate) is produced endogenously from methionine and ATP by action of the enzyme methionine adenosyltransferase and is an important orally active methyl group donor.

CJ-13610 is an inhibitor of 5-lipoxygenase (5-LO) that inhibits 5-LO product formation in human polymorphonuclear leukocytes (PMNLs) challenged with A23187 in vitro (IC50 = 70 nM).

13,14-dihydro-15-keto Prostaglandin E1 (PGE1) is a metabolite of PGE1 with much reduced biological activity.

A CB 2 receptor agonist

A selective CB 2 receptor agonist

URB937 is an orally active, peripherally restricted, selective inhibitor of fatty acid amide hydrolase (FAAH) with an IC 50 of 26.8nM.

ML221 is a potent apelin (APJ) functional antagonist

Menthol is a natural painkiller. Menthol stimulates the cold receptors by inhibiting the Ca++ current in the cell membrane of neurons, thus producing a cold feeling.

LP-935509 is an orally active, potent, selective, ATP-competitive and brain-penetrant inhibitor of adaptor protein-2 associated kinase 1 (AAK1) with an IC50 of 3.3 nM and a Ki of 0.9 nM, respectively.

A P2X 4 receptor antagonist

Probenecid-d14 is intended for use as an internal standard for the quantification of probenecid by GC- or LC-MS.

(R)-AM1241 binds to cannabinoid (CB) receptors and has greater than 100-fold selectivity for the CB2 over the CB1 receptor (Kis = 15 and 5,000 nM, respectively, in a membrane assay using human receptors).

(S)-AM1241 binds to cannabinoid (CB) receptors and is selective for the CB2 over the CB1 receptor (Kis = 658 and >10,000 nM, respectively, in a membrane assay using human receptors).

8-methyl Nonanoic Acid is the precursor of 8-methyl-nonenoic acid and is involved in the synthesis of capsaicin.

Decursinol angelate is a pyranocoumarin that has been found in the Korean medicinal herb A.