GLPBio

DBCO-PEG3-GGFG-Exatecan

Catalog No.: GC78795Purity:>95.50%
COASDSData Sheet
DBCO-PEG3-GGFG-Exatecan is a Drug-linker conjugate for ADC.

Products are for research use only. Not for human use. We do not sell to patients.

DBCO-PEG3-GGFG-Exatecan
Cas No.: 2754384-71-7
1mgIn Stock
$360.00
1
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    618, 1017–1023 (2023)
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    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    183(7):1867-1883 (2020)
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    388(6745) (2025)
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    35, 97–116 (2025)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

Description

DBCO-PEG3-GGFG-Exatecan is a Drug-linker conjugate for ADC. DBCO-PEG3-GGFG-Exatecan contains the ADC linker (DBCO-PEG3-GGFG) and a DNA topoisomerase I inhibitor Exatecan [1].

In Vitro, DCBPR2002-4 (DBCO-PEG3-GGFG-Exatecan construct) (72 h) can inhibit the viability of OVCAR-3 ovarian cancer cells expressing mesothelin in vitro, with its IC50 being 130.2 nM[1].

References:
[1]. CHUANG,Shih-Hsien, et al. Antibody-drug conjugates containing an anti-mesothelin antibody and uses thereof. WO2021248048 A2. 2021-12-09.

Product Documents

Purity:>95.50%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
2754384-71-7
Molecular Formula
C67H70FN9O14
Molecular Weight
1244.32
Solubility
DMSO: 50 mg/mL (40.18 mM; Need ultrasonic)
Storage
Store at -20°C, protect from light, stored under nitrogen
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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