GLPBio

dBRD9

Catalog No.: GC50518Purity:>98%
COASDSData Sheet
Potent and selective BRD9 degrading PROTAC

Products are for research use only. Not for human use. We do not sell to patients.

dBRD9
Cas No.: 2341840-98-8
10mM (in 1mL DMSO)In Stock
$387.00
1
1mgIn Stock
$113.00
1
5mgIn Stock
$284.00
1
10mgIn Stock
$448.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citations

1 publicationsPublications from researchers using this product

Description

PROTAC® composed of the BRD9 inhibitor BI 7273 conjugated to the cereblon E3 ligase ligand pomalidomide . Potent and selective degrader of BRD9 (IC50 = 56.6 nM in MOLM-13 cells). Does not degrade BRD4 or BRD7 at concentrations up to 5 μM. Displays antiproliferative effects in human AML cell lines. PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Remillard et al (2017) Degradation of the BAF complex factor BRD9 by heterobifunctional ligands. Angew.Chem.Int.Ed.Engl. 56 5738 PMID:28418626

Chemical Properties

CAS No.
2341840-98-8
SMILES
COC1=CC(C2=CN(C(C3=CN=CC=C23)=O)C)=CC(OC)=C1CN(CC(NCCOCCOCCNC4=C5C(N(C(C5=CC=C4)=O)C6CCC(NC6=O)=O)=O)=O)C.Cl.Cl
Molecular Formula
C40H45N7O10.2HCl
Molecular Weight
856.75
Solubility
Water 17.14 mg/ml, DMSO 42.84 mg/ml
Storage
Store at -20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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