GLPBio

DCEBIO

Catalog No.: GC15750Purity:>99.50%
COASDSData Sheet
Stimulates Cl- secretion

Products are for research use only. Not for human use. We do not sell to patients.

DCEBIO
Cas No.: 60563-36-2
10mM (in 1mL DMSO)In Stock
$79.00
1
5mgIn Stock
$72.00
1
10mgIn Stock
$112.00
1
25mgIn Stock
$225.00
1
50mgIn Stock
$360.00
1
100mgIn Stock
$540.00
1
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Citations

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    Nature
    641, 529–536 (2025)
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    628, 630–638 (2024)
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    632, 686–694 (2024)
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    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    388(6745) (2025)
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    35, 97–116 (2025)
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    34, 683–706 (2024)
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    33, 273–287 (2023)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

Description

DCEBIO, a derivative of 1-EBIO, is an extremely potent activator of Cl－ secretion in T84 colonic cells[1]. DCEBIO stimulates Cl－ secretion via the activation of hIK1 K＋ channels and the activation of an apical membrane Cl－ conductance[2].

References:
[1]. Hamilton KL,et al. DCEBIO stimulates Cl- secretion in the mouse jejunum. Am J Physiol Cell Physiol. 2006 Jan;290(1):C152-64.
[2]. Singh S, et al. Benzimidazolone activators of chloride secretion: potential therapeutics for cystic fibrosis and chronic obstructive pulmonary disease. J Pharmacol Exp Ther. 2001 Feb;296(2):600-11.

Product Documents

Purity:>99.50%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
60563-36-2
Chemical Name
5,6-dichloro-1-ethyl-1H-benzo[d]imidazol-2(3H)-one
SMILES
ClC(C=C(C(NC1=O)=C2)N1CC)=C2Cl
Molecular Formula
C9H8Cl2N2O
Molecular Weight
231.08
Solubility
<23.11mg/ml in ethanol; <23.11mg/ml in DMSO
Storage
Store at RT
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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