1-Methyladenosine is a modified nucleoside that carries a positive charge and strongly disrupts canonical Watson-Crick-Franklin basepairing [1]. The modification based on 1-Methyladenosine can increase the translation of PPARδ, thereby triggering cholesterol synthesis, activating the Hedgehog signaling pathway, and ultimately promoting the self-renewal of liver cancer stem cells and tumor formation [2]. 1-Methyladenosine is widely used as a tumor marker, since the content is associated with the occurrence and development of cancer, enabling the early detection of genistein-induced breast cancer in rats [3]. 1-Methyladenosine is widely used as a biochemical indicator to assess the progression of rheumatoid arthritis[4].
References:
[1] Zhou H, Rauch S, Dai Q, et al. Evolution of a reverse transcriptase to map N 1-methyladenosine in human messenger RNA[J]. Nature methods, 2019, 16(12): 1281-1288.
[2] Wang Y, Wang J, Li X, et al. N 1-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism[J]. Nature communications, 2021, 12(1): 6314.
[3] Banys K, Giebultowicz J, Sobczak M, et al. Effect of genistein supplementation on the progression of neoplasms and the level of the modified nucleosides in rats with mammary cancer[J]. in vivo, 2021, 35(4): 2059-2072.
[4] Tebib J G, Reynaud C, Cedoz J P, et al. Relationship between urinary excretion of modified nucleosides and rheumatoid arthritis process[J]. British journal of rheumatology, 1997, 36(9): 990-995.